“…Delightedly, the past few years have witnessed the rapid development of an electrospinning technique, and it has proved to be an effective method for constructing flexible and continuous CPL nanofibers with a controlled morphology, uniformity, and the desired optical properties. − The advantages of electrospinning include ease of operation, reliable reproducibility, and low cost. Moreover, multilevel structured nanofibers have also been realized by electrospinning. , For instance, Janus nanofibers composed of two distinct materials or phases within a single fiber can be prepared by using a parallel electrospinning nozzle. − It can be expected that introducing a Janus structure into CPL nanofibers has many scientific significances, including (1) offering more options for chiral and fluorescence substances, especially the ones with different compatibility (e.g., one is water-soluble and the other is oil-soluble), and (2) providing a spatial isolation between a chiral substance and a fluorescence substance for better understanding the CPL generation mechanism/process. Unfortunately, to the best of our knowledge, there has been no report concerning CPL-active Janus nanofibers so far.…”