Wireless enzyme sensor system for real-time monitoring of blood glucose levels in fish

Endo, Hideki; Yonemori, Yuki; Hibi, Kyoko; Ren, Hongyan; Hayashi, Tetsuhito; Tsugawa, Wakako; Sode, Koji

doi:10.1016/j.bios.2008.08.038

Cited by 71 publications

(42 citation statements)

References 29 publications

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“…The widely studied amperometric glucose sensors fell into two major types, the enzymatic and enzymeless sensors. Enzymatic sensors showed good selectivity and high sensitivity for glucose detection (Adanyi et al, 2004;Ricci et al, 2005;Wang and Angnes, 1992), even used in vivo (Endo et al, 2009;Poscia et al, 2003). However, owing to the nature of enzymes, the most common and serious problem of enzymatic glucose sensors lies in their lack of long-term stability.…”

Section: Introductionmentioning

confidence: 99%

An improved sensitivity nonenzymatic glucose biosensor based on a Cu O modified electrode

Zhang

et al. 2010

Biosensors and Bioelectronics

178

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Section: Introductionmentioning

confidence: 99%

An improved sensitivity nonenzymatic glucose biosensor based on a Cu O modified electrode

Zhang

et al. 2010

Biosensors and Bioelectronics

178

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“…The ISF glucose levels range from 87 to 101% of blood glucose levels [14] and, consequently, several needle-type biosensor systems for use in humans have been developed for subcutaneous, intramuscular, and intra-adipose tissue implantation, respectively, to estimate blood glucose levels [8,15]. We have recently developed a biosensor system for continuous blood glucose monitoring in freshwater fish (Nile tilapia, Oreochromis niloticus) which measures glucose in the ISF under the scleral surface of the eyeball (referred to hereafter as EISF) [16,17]. EISF was considered to be a suitable site for sensor implantation to obtain glucose samples, and we found a close correlation between glucose concentrations in the EISF and those in the blood.…”

Section: Introductionmentioning

confidence: 99%

Wireless monitoring of blood glucose levels in flatfish with a needle biosensor

Endo

Takahashi

Murata³

et al. 2010

Fish Sci

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A wireless biosensor system was developed for the continuous measurement of blood glucose levels in flatfish. The biosensor was implanted in the interstitial fluid under the scleral surface of the eyeball (EISF) to investigate the relationship between EISF and blood glucose levels. EISF glucose levels were found to be correlated with those in the blood and to be approximately the same as blood glucose levels in the range of 7-25 mg dl -1 . A needle-type biosensor was prepared for the continuous EISF glucose monitoring in flatfish. A working electrode was constructed using platinum iridium wire, and glucose oxidase was immobilized to the electrode. The biosensor was inserted into the EISF of flatfish for sensor implantation. A 650-mV potential (vs. Ag/AgCl) was applied by a wireless potentiostat to the working electrode for the amperometric glucose measurement. We investigated whether glucose in the EISF can be determined in vivo.The estimated glucose levels using a one-point calibration method were correlated with actual blood glucose levels. In conclusion, using a wireless biosensor system, we were able to monitor blood glucose levels in flatfish under freeswimming conditions for 16 h.

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“…However, within the living body, there is concomitant electrooxidation of many interfering species, such as AA, DA, UA, alcohol and so on [25][26]. Therefore, the electroreduction method was carried out in this paper in order to remove the serious interference in the practical sample analysis.…”

Section: Interference Study and Performance Evaluationmentioning

confidence: 99%

A Novel Biosensor for Determination of Glucose Based on MWCNTs/ZrO</sub>2</sub>-Pt Nanocomposite

Ibrahim¹,

Alsharif²,

Keshk³

2017

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Abstarct:Multiwalled carbon nanotubes/ZrO 2 -Pt(MWCNTs/ZrO 2 -Pt) composite was synthesized by a chemical route. The structure and composition of the MWCNTs/ZrO 2 -Pt composite were confirmed by means of transmission electron microscopy, and Raman spectroscopy. Due to the good electrochemical activity property of MWCNTs/ZrO 2 -Pt composite, a glucose biosensor was constructed by absorbing glucose oxidase (GOD) on the hybrid material. A direct electron transfer process is observed at the MWCNTs/ZrO 2 -Pt/GOD-modified glassy carbon electrode. The glucose biosensor has a linear range from 4.0 to 24.0 mM, which is suitable for glucose determination by real samples. It should be worthwhile noting that, from 4.0 to 12.0mM, the cathodic peak currents of the biosensor decrease linearly with increasing the glucose concentrations in human blood. Meanwhile, the resulting biosensor can also prevent the effects of interfering species. Moreover, the biosensor exhibits satisfying reproducibility, good operational stability and storage stability. Therefore, the MWCNTs/ZrO 2 -Pt /GOD biocomposite could be promisingly applied to determine blood sugar concentration in the practical clinical analysis.

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Wireless enzyme sensor system for real-time monitoring of blood glucose levels in fish

Cited by 71 publications

References 29 publications

An improved sensitivity nonenzymatic glucose biosensor based on a Cu O modified electrode

An improved sensitivity nonenzymatic glucose biosensor based on a Cu O modified electrode

Wireless monitoring of blood glucose levels in flatfish with a needle biosensor

A Novel Biosensor for Determination of Glucose Based on MWCNTs/ZrO</sub>2</sub>-Pt Nanocomposite

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Wireless enzyme sensor system for real-time monitoring of blood glucose levels in fish

Cited by 71 publications

References 29 publications

An improved sensitivity nonenzymatic glucose biosensor based on a Cu O modified electrode

An improved sensitivity nonenzymatic glucose biosensor based on a Cu O modified electrode

Wireless monitoring of blood glucose levels in flatfish with a needle biosensor

A Novel Biosensor for Determination of Glucose Based on MWCNTs/ZrO&lt;/sub&gt;2&lt;/sub&gt;-Pt Nanocomposite

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A Novel Biosensor for Determination of Glucose Based on MWCNTs/ZrO</sub>2</sub>-Pt Nanocomposite