Wireless miniaturized in-vivo near infrared imaging

Muehlemann, Thomas; Haensse, Daniel; Wolf, M.

doi:10.1364/oe.16.010323

Cited by 145 publications

(110 citation statements)

References 15 publications

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“…Hence, CW fNIRI instruments come in comparably simple setups, allowing specialization towards wearable, miniaturized and/or wireless applications, and can partially be built from off the shelf components at low cost (Flexman et al, 2012;Muehlemann et al, 2008;Q. Zhang et al, 2011;Vaithianathan et al, 2004).…”

Section: Technological Design Aspects Of Fnirimentioning

confidence: 99%

“…If the emission spectrum of the source is known, however, weighted averaging approaches exist to correct the extinction coefficients (and possibly also the differential path length factors) used for the MBLL (Muehlemann et al, 2008;Wahr et al, 1996;Zhang et al, 2001).…”

Section: Light Sources For Fniri Instrumentsmentioning

confidence: 99%

“…The sources and detectors can be placed directly onto the 13 skin (such as, e.g., in Bozkurt et al, 2005or in Muehlemann et al, 2008, or the light can be guided by optical fibers to probes on the head (Fig. 4), where the fibers are fixed by appropriate fiber holders (Giacometti and Diamond, 2013).…”

Section: Probe Designmentioning

confidence: 99%

“…In addition, time resolved systems have a lower time resolution, are more expensive and the time of flight is generally a more noisy parameter than the intensity and therefore not useful for detecting small functional activations. In contrast, CW systems are relatively low cost, can be miniaturized and wireless systems and can be applied unobtrusively in everyday life situations or even freely moving animals (Muehlemann et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

Scholkmann¹,

Kleiser²,

Metz³

et al. 2014

NeuroImage

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1,523

1,394

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This year marks the 20th anniversary of functional near-infrared spectroscopy and imaging (fNIRS/fNIRI). As the vast majority of commercial instruments developed until now are based on continuous wave technology, the aim of this publication is to review the current state of instrumentation and methodology of continuous wave fNIRI. For this purpose we provide an overview of the commercially available instruments and address instrumental aspects such as light sources, detectors and sensor arrangements. Methodological aspects, algorithms to calculate the concentrations of oxy-and deoxyhemoglobin and approaches for data analysis are also reviewed. From the single-location measurements of the early years, instrumentation has progressed to imaging initially in two dimensions (topography) and then three (tomography). The methods of analysis have also changed tremendously, from the simple modified Beer-Lambert law to sophisticated image reconstruction and data analysis methods used today. Due to these advances, fNIRI has become a modality that is widely used in neuroscience research and several manufacturers provide commercial instrumentation. It seems likely that fNIRI will become a clinical tool in the foreseeable future, which will enable diagnosis in single subjects. This year marks the 20th anniversary of functional near-infrared spectroscopy and imaging (fNIRS/fNIRI). As the vast majority of commercial instruments developed until now are based on continuous wave technology, the aim of this publication is to review the current state of instrumentation and methodology of continuous wave fNIRI. For this purpose we provide an overview of the commercially available instruments and address instrumental aspects such as light sources, detectors and sensor arrangements. Methodological aspects, algorithms to calculate the concentrations of oxy-and deoxyhemoglobin and approaches for data analysis are also reviewed. From the single-location measurements of the early years, instrumentation has progressed to imaging initially in two dimensions (topography) and then three (tomography). The methods of analysis have also changed tremendously, from the simple modified Beer-Lambert law to sophisticated image reconstruction and data analysis methods used today. Due to these advances, fNIRI has become a modality that is widely used in neuroscience research and several manufacturers provide commercial instrumentation. It seems likely that fNIRI will become a clinical tool in the foreseeable future, which will enable diagnosis in single subjects. Contents

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Section: Technological Design Aspects Of Fnirimentioning

confidence: 99%

Section: Light Sources For Fniri Instrumentsmentioning

confidence: 99%

Section: Probe Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

Scholkmann¹,

Kleiser²,

Metz³

et al. 2014

NeuroImage

Self Cite

1,523

1,394

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show abstract

“…In order to test the extent to which the six different methods are resilient to MAs, we measured the light attenuation during four different experimental tasks using a novel CW NIRS device, the OxyPrem, which is similar to a previously developed wireless spectrophotometer (Muehlemann et al 2008). The device features two light detectors and four sources at two different SDSs (1.5 and 2.5 cm), and performs measurement at three wavelengths (760, 805 and 870 nm).…”

Section: Experimental Protocolmentioning

confidence: 99%

Measuring tissue hemodynamics and oxygenation by continuous-wave functional near-infrared spectroscopy—how robust are the different calculation methods against movement artifacts?

Scholkmann¹,

Metz

Wolf

2014

Physiol. Meas.

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Continuous-wave near-infrared spectroscopy and imaging enable tissue hemodynamics and oxygenation to be determined non-invasively. Movements of the investigated subject can cause movement artifacts (MAs) in the recorded signals. The strength and type of MAs induced depend on the measurement principle. The aim of the present study was to investigate the quantitative relationship between different single-distance (SD) and multi-distance (MD) measurement methods and their susceptibility to MAs. We found that each method induces MAs to a different degree, and that MD methods are more robust against MAs than SD methods. AbstractContinuous-wave near-infrared spectroscopy and imaging enable tissue hemodynamics and oxygenation to be determined non-invasively. Movements of the investigated subject can cause movement artifacts (MAs) in the recorded signals. The strength and type of MAs induced depend on the measurement principle. The aim of the present study was to investigate the quantitative relationship between different single-distance (SD) and multi-distance (MD) measurement methods and their susceptibility to MAs. We found that each method induces MAs to a different degree, and that MD methods are more robust against MAs than SD methods.

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Improving the quantitative accuracy of cerebral oxygen saturation in monitoring the injured brain using atlas based Near Infrared Spectroscopy models

Clancy

Belli

Davies

et al. 2016

Journal of Biophotonics

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The application of Near Infrared Spectroscopy (NIRS) for the monitoring of the cerebral oxygen saturation within the brain is well established, albeit using temporal data that can only measure relative changes of oxygenation state of the brain from a baseline. The focus of this investigation is to demonstrate that hybridisation of existing near infrared probe designs and reconstruction techniques can pave the way to produce a system and methods that can be used to monitor the absolute oxygen saturation in the injured brain. Using registered Atlas models in simulation, a novel method is outlined by which the quantitative accuracy and practicality of NIRS for specific use in monitoring the injured brain, can be improved, with cerebral saturation being recovered to within 10.1 ± 1.8% of the expected values.

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Wireless miniaturized in-vivo near infrared imaging

Cited by 145 publications

References 15 publications

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

Measuring tissue hemodynamics and oxygenation by continuous-wave functional near-infrared spectroscopy—how robust are the different calculation methods against movement artifacts?

Improving the quantitative accuracy of cerebral oxygen saturation in monitoring the injured brain using atlas based Near Infrared Spectroscopy models

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