Wireless Motility Capsule Test in Children with Upper Gastrointestinal Symptoms

Green, Alex D.; Belkind‐Gerson, Jaime; Surjanhata, Brian; Mousa, Hayat; Kuo, Braden; Lorenzo, Carlo Di

doi:10.1016/j.jpeds.2012.11.040

Cited by 53 publications

(48 citation statements)

References 12 publications

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“…Pediatric data on dietary interventions remain very limited. A few older, small studies in infants document improved gastric emptying with medium‐chain compared to long‐chain triglycerides and more rapid emptying with whey‐hydrolysate formula . One study in premature infants showed no difference in gastric emptying between whey and casein predominant formulas …”

Section: Resultsmentioning

confidence: 99%

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Kovacic

Elfar

Rosen

et al. 2019

Neurogastroenterology Motil

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Background Due to scarcity of scientific literature on pediatric gastroparesis, there is a need to summarize current evidence and identify areas requiring further research. The aim of this study was to provide an evidence‐based review of the available literature on the prevalence, pathogenesis, clinical presentation, diagnosis, treatment, and outcomes of pediatric gastroparesis. Methods A search of the literature was performed using the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines with the following databases: PubMed, EMBASE, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, and Web of Science. Two independent reviewers screened abstracts for eligibility. Key Results Our search yielded 1085 original publications, 135 of which met inclusion criteria. Most articles were of retrospective study design. Only 12 randomized controlled trials were identified, all of which were in infants. The prevalence of pediatric gastroparesis is unknown. Gastroparesis may be suspected based on clinical symptoms although these are often non‐specific. The 4‐hour nuclear scintigraphy scan remains gold standard for diagnosis despite lack of pediatric normative comparison data. Therapeutic approaches include dietary modifications, prokinetic drugs, and postpyloric enteral tube feeds. For refractory cases, intrapyloric botulinum toxin and surgical interventions such as gastric electrical stimulation may be warranted. Most interventions still lack rigorous supportive data. Conclusions Diagnosis and treatment of pediatric gastroparesis are challenging due to paucity of published evidence. Larger and more rigorous clinical trials are necessary to improve outcomes.

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Section: Resultsmentioning

confidence: 99%

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Kovacic

Elfar

Rosen

et al. 2019

Neurogastroenterology Motil

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“…Data on the WMC in pediatrics is very limited. One single‐center pediatric study (n = 21) found the WMC had a sensitivity of 100% and specificity of 50% for detecting GP when compared to the GES at 2 hours (the protocol at the institution was a 2‐hour rather than a 4‐hour GES) . The authors argue that allowing an additional 2 hours might have identified more cases of GP.…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

Childhood gastroparesis is a unique entity in need of further investigation

Febo‐Rodriguez

Chumpitazi

Shulman

2019

Neurogastroenterology Motil

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Background Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures. Purpose The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.

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“…Although the water load test may not be useful for identification of pediatric FD due to suboptimal sensitivity, children diagnosed with FD often have abnormal test results [36] . In a controlled study by Schurman et al [36] , 68 pediatric patients with FGIDs and 26 healthy children completed the Behavioral Assessment Scale for Children- [36] 28 FD Hoffman et al [37] 15 FD Chitkara et al [38] 101 CAP Anderson et al [39] Gastric barostat 16 FD Hoffman et al [47] 10 RAP, 10 IBS Di Lorenzo et al [48] Electromechanical function Gastric emptying breath test 28 FD Hoffman et al [37] 15 FD Chitkara et al [38] Gastric emptying scintigraphy 57 FD Chitkara et al [76] 30 FD Friesen et al [77] Gastric Emptying ultrasound 41 FD Devanarayana et al [78] 42 FD Boccia et al [79] Accommodation ultrasound 20 RAP Olafsdottir et al [94] 20 RAP Olafsdottir et al [95] 20 non-ulcer dyspepsia Cucchiara et al [96] SPECT 15 FD Chitkara et al [38] Electrogastrogram 30 FD Friesen et al [77] 15 FD Chen et al [106] 7 non-ulcer dyspepsia Di Lorenzo et al [114] Antroduodenal manometry 11 non-ulcer dyspepsia Cucchiara et al [109] 34 non-ulcer dyspepsia Di Lorenzo et al [110] 7 non-ulcer dyspepsia Di Lorenzo et al [114] Wireless motility capsule 22 mixed upper GI symptoms Green et al [118] [138] Citalopram 25 RAP Campo et al [140] Famotidine 25 RAP with dyspepsia See et al [148] Omeprazole 169 FD Dehghani et al [149] Cisapride 10 non-ulcer dyspepsia Riezzo et al [154] Erythromycin 7 FD Cucchiara et al [172] Cyproheptadine 44 FD Rodriguez et al [187] Peppermint oil 42 IBS Kline et al [191] Gut-directed hypnotherapy 52 FAP or IBS Vlieger et al [200] 34 ...…”

Section: Water Load Testmentioning

confidence: 99%

“…It is used to study prokinetic medication efficacy [116] and to describe an adult irritable bowel syndrome cohort [117] . Data is not yet available in adult or pediatric dyspeptics, but an initial study suggests the WMC is a sensitive detector of motor abnormalities in pediatric patients with upper gastrointestinal symptoms [118] .…”

Section: Wireless Motility Capsulementioning

confidence: 99%

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

Rosen

Cocjin

Schurman

et al. 2014

WJGPT

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Functional gastrointestinal disorders (FGID) are common clinical syndromes diagnosed in the absence of biochemical, structural, or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age, geography, and culture. Etiology of abdominal pain associated FGIDs, including functional dyspepsia (FD), remains incompletely understood, but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD, with focus on pediatric data when available, and provides a summary of potential therapeutic targets. Visceral sensitivity and intestinal electromechanical function both are demonstrated to be altered in some FD patients and are potential targets for treatment. Limited studies in pediatric FD are available, but available evidence supports adult data that targeting visceral hypersensitivity and electromechanical dysfunction is warranted, particularly in the context of the biopsychosocial model. Future studies in pediatrics are needed to determine optimal therapy and appropriate patient application.Rosen JM, Cocjin JT, Schurman JV, Colombo JM, Friesen CA. Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia. World

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Wireless Motility Capsule Test in Children with Upper Gastrointestinal Symptoms

Cited by 53 publications

References 12 publications

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Childhood gastroparesis is a unique entity in need of further investigation

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

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