Wireless opto-electro neural interface for experiments with small freely behaving animals

Jia, Yaoyao; Khan, Wasif; Lee, Byunghun; Fan, Bin; Madi, Fatma; Weber, Arthur J.; Li, Wen; Ghovanloo, Maysam

doi:10.1088/1741-2552/aac810

Cited by 40 publications

(21 citation statements)

References 45 publications

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“…Several researchers have also introduced variations of the Utaharray combined with miniaturized optical components to acquire high-resolution electrical neural signals following optical neurostimulation [127128]. Similarly, previous studies have reported the success of BMI systems based on optogenetic neuromodulation and electrical neural recordings in small animals [129130131132133134135]. For example, Liu et al developed a compact optogenetics system using graphene electrodes to reduce artifacts [136].…”

Section: Multi-modal Neural Probes To Measure Both Electrical and Optmentioning

confidence: 99%

Implantable Neural Probes for Brain-Machine Interfaces ? Current Developments and Future Prospects

et al. 2018

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A Brain-Machine interface (BMI) allows for direct communication between the brain and machines. Neural probes for recording neural signals are among the essential components of a BMI system. In this report, we review research regarding implantable neural probes and their applications to BMIs. We first discuss conventional neural probes such as the tetrode, Utah array, Michigan probe, and electroencephalography (ECoG), following which we cover advancements in next-generation neural probes. These next-generation probes are associated with improvements in electrical properties, mechanical durability, biocompatibility, and offer a high degree of freedom in practical settings. Specifically, we focus on three key topics: (1) novel implantable neural probes that decrease the level of invasiveness without sacrificing performance, (2) multi-modal neural probes that measure both electrical and optical signals, (3) and neural probes developed using advanced materials. Because safety and precision are critical for practical applications of BMI systems, future studies should aim to enhance these properties when developing next-generation neural probes.

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Section: Multi-modal Neural Probes To Measure Both Electrical and Optmentioning

confidence: 99%

Implantable Neural Probes for Brain-Machine Interfaces ? Current Developments and Future Prospects

et al. 2018

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“…[138] The second approach is implementing a wireless readout technology widely used for epidermal electronics. Wireless readout allows for a higher degree of freedom in animal experiments [129,139] as well as for humans. [140] Recently, even smaller than 1 mm size devices with CNT electrodes have been reported with such wireless communication abilities reducing further the motion induced damage to the brain tissue.…”

Section: Challenges In Signal Recording and Stimulationmentioning

confidence: 99%

Soft Electronics Based on Stretchable and Conductive Nanocomposites for Biomedical Applications

Zambrano

Renz

Ruff

et al. 2020

Adv Healthcare Materials

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Research on the field of implantable electronic devices that can be directly applied in the body with various functionalities is increasingly intensifying due to its great potential for various therapeutic applications. While conventional implantable electronics generally include rigid and hard conductive materials, their surrounding biological objects are soft and dynamic. The mechanical mismatch between implanted devices and biological environments induces damages in the body especially for long‐term applications. Stretchable electronics with outstanding mechanical compliance with biological objects effectively improve such limitations of existing rigid implantable electronics. In this article, the recent progress of implantable soft electronics based on various conductive nanocomposites is systematically described. In particular, representative fabrication approaches of conductive and stretchable nanocomposites for implantable soft electronics and various in vivo applications of implantable soft electronics are focused on. To conclude, challenges and perspectives of current implantable soft electronics that should be considered for further advances are discussed.

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“…More recently, Jia et al developed a battery‐powered flexible and implantable ECoG recording and optical stimulation device using commercially available μ‐ILEDs (220 × 270 × 50 μm 3 ). [ 231 ] A reflow soldering process mechanically holds μ‐ILEDs at desired locations and electrically connects the μ‐ILEDs to prepatterned interconnects. In vivo experiment demonstrates that the device can achieve the bidirectional neuromodulation of primary visual cortex neurons in freely moving rats using Bluetooth data communication for up to 21 days after implantation.…”

Section: Multimodal Microsystemsmentioning

confidence: 99%

Advanced Electrical and Optical Microsystems for Biointerfacing

Obaid

Chen

2020

Advanced Intelligent Systems

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Electrical and optical biointerfaces have contributed considerably to understanding biological systems. Recent advances in biocompatible materials, structure designs, and fabrication techniques have established flexible and minimally invasive electronic/optoelectronic platforms that laminate onto targeted surface regions or implant into precise locations of biosystems to monitor and control various biological processes at cell, tissue, and organ levels. Herein, recent progress in advanced biointegrated electrical and optical platforms is discussed. An overview of materials and device designs to form flexible and even stretchable electrodes is presented. Strategies to reduce tissue damage and foreign‐body response to improve chronic stability are described. State‐of‐the‐art wearable and implantable microsystems with/without wireless capabilities for bioelectrical sensing and stimulation, optical recording and modulation, and multimodal operation are highlighted. In conclusion, a discussion of the remaining obstacles for future research in these areas is provided.

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Wireless opto-electro neural interface for experiments with small freely behaving animals

Abstract: The proposed WOENI device is potentially a versatile tool in the studies that involve long-term optogenetic neuromodulation.

Cited by 40 publications

References 45 publications

Implantable Neural Probes for Brain-Machine Interfaces ? Current Developments and Future Prospects

Implantable Neural Probes for Brain-Machine Interfaces ? Current Developments and Future Prospects

Soft Electronics Based on Stretchable and Conductive Nanocomposites for Biomedical Applications

Advanced Electrical and Optical Microsystems for Biointerfacing

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