Wireless, Skin‐Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring (Adv. Healthcare Mater. 17/2021)

Liu, Claire; Kim, Jin‐Tae; Kwak, Sung Soo; Hourlier-Fargette, Aurélie; Avila, Raudel; Vogl, Jamie; Tzavelis, Andreas; Lee, Jong Yoon; Kim, Dong Hyun; Ryu, Dennis; Fields, Kelsey B.; Ciatti, Joanna L.; Li, Shupeng; Irie, Masahiro; Bradley, Allison; Shukla, Avani; Chavez, Jairo; Dunne, Emma C.; Kim, Seung Sik; Kim, Jung-Woo; Park, Jun Bin; Jo, Han Heul; Kim, Joohee; Johnson, Matthew T.; Kwak, Jean Won; Madhvapathy, Surabhi R.; Xu, Shuai; Rand, Casey M.; Marsillio, Lauren; Hong, Sue; Huang, Yonggang; Weese‐Mayer, Debra E.; Rogers, John A.

doi:10.1002/adhm.202170080

Cited by 5 publications

(3 citation statements)

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“…Mechanotransduction is a biological process by which sensory cells convert biomechanical stimuli into cellular signals and significantly impact the development, regulation, and regeneration of organ functions. − Monitoring and measurement of vital biomechanical information such as blood pressure, cardiac pulsation, intraocular pressure, and articular movements are crucial in the early diagnosis of chronic and acute diseases and provide comprehensive assessments for tracking patient rehabilitation after reconstructive surgeries. − Moreover, perceiving external mechanical cues in the skin-mimetic approach facilitates restoring tactile sensation for injured people. − In fact, mechanical information from both the human body and external stimuli is usually aliased and accompanied by artifacts from inevitable movements (e.g., breathing, walking, and swallowing), whereby the transmitted data possesses serialized structure with variable amplitude, duration (pulse width), and frequency. Traditional methods that merely increase the sensitivity of sensors or use differential amplification circuits cannot precisely distinguish signals of interest (SOI) due to the indiscriminate enhancement or suppression of signals. , Although recent signal segmentation methods, such as bandpass filtering, independent and principal component analysis, can reduce the interference of noise on the SOI, they usually require specific prior information or complex iterative procedure, raising the computational cost and restricting the recognizable patterns .…”

Section: Introductionmentioning

confidence: 99%

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Chen

Ren

et al. 2023

ACS Nano

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A tactile sensor needs to perceive static pressures and dynamic forces in real-time with high accuracy for early diagnosis of diseases and development of intelligent medical prosthetics. However, biomechanical and external mechanical signals are always aliased (including variable physiological and pathological events and motion artifacts), bringing great challenges to precise identification of the signals of interest (SOI). Although the existing signal segmentation methods can extract SOI and remove artifacts by blind source separation and/or additional filters, they may restrict the recognizable patterns of the device, and even cause signal distortion. Herein, an in-memory tactile sensor (IMT) with a dynamically adjustable steep-slope region (SSR) and nanocavity-induced nonvolatility (retention time >1000 s) is proposed on the basis of a machano-gated transistor, which directly transduces the tactile stimuli to various dope states of the channel. The programmable SSR endows the sensor with a critical window of responsiveness, realizing the perception of signals on demand. Owing to the nonvolatility of the sensor, the mapping of mechanical cues with high spatiotemporal accuracy and associative learning between two physical inputs are realized, contributing to the accurate assessment of the tissue health status and ultralow-power (about 25.1 μW) identification of an occasionally occurring tremor.

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Section: Introductionmentioning

confidence: 99%

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Chen

Ren

et al. 2023

ACS Nano

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“…As an important sub‐branch of flexible electronics, [ 1–3 ] wearable sensors [ 4–6 ] have demonstrated a number of advantageous features over traditional rigid devices and found promising applications in the fields of soft robotics, [ 7–9 ] artificial organs, [ 10–12 ] rehabilitation, [ 13–15 ] and disease diagnoses. [ 16–18 ] Among all kinds of flexible sensors, piezoresistive pressure sensors are of great interest as electronic skins, [ 19–21 ] wearable monitors, [ 22–24 ] and human–machine interfaces [ 25,26 ] for their easy signal readout and collection, simple device structure, low energy consumption, and high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Stiffness Engineering of Ti₃C₂T_X MXene‐Based Skin‐Inspired Pressure Sensor with Broad‐Range Ultrasensitivity, Low Detection Limit, and Gas Permeability

Hui

Wang

Yang

et al. 2022

Adv Materials Inter

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of flexible sensors, piezoresistive pressure sensors are of great interest as electronic skins, [19][20][21] wearable monitors, [22][23][24] and human-machine interfaces [25,26] for their easy signal readout and collection, simple device structure, low energy consumption, and high sensitivity. [27] For instance, remote healthcare becomes possible with the help of flexible mechanosensors, which can be directly attached to the human body enabling timely and wireless acquisition of vital physiological signals via continuously monitoring the blood pressure, heartbeat speed, and joint movement. [28,29] Moreover, pressure sensors can provide haptic feedback when combined with robotic arms, improving the reliability and efficacy of industrial production. [30] Nevertheless, the bottleneck existing in the field of pressure sensor design remains to be the trade-off between sensitivity and sensing range.Human skin, which is the largest organ of the body, possesses enormous functions of protection, excretion, temperature regulation, and perception. [7] Skin basically contains epidermis as the protective layer, dermis as a cushion layer for buffering stress/strain, mechanoceptor connected with dermis for amplifying and efficiently transferring tactile stimuli, and sweat glands for temperature regulation. [31,32] Inspired by the interlocked microstructures of epidermis and dermis, piezoresistive pressure sensor consisting of two conductive layers stacked in a face-to-face manner has been widely explored due to its large output current changes upon loading and its performance has been much enhanced by introducing High sensitivity and broad sensing range are considered as two crucial parameters toward flexible and wearable piezoresistive pressure sensors for human healthcare, human-machine interfaces, robots, and so on. Though various strategies are developed to improve the sensor performance, the trade-off between sensitivity and sensing range remains a bottleneck for device design. Besides, conventional pressure sensors without gas permeability normally cause discomfort and inflammation to the human skin. Herein, enlightened by the functions and structure of the human skin, this article proposes a stiffness engineering strategy for constructing Ti 3 C 2 T X MXene-based porous spinosum structure to boost sensitivity over a broad detection range. Consequently, the as-fabricated pressure sensor exhibits superior performance, including ultrahigh sensitivity of 367 kPa −1 over a widened detection range, a low detection limit of 1 Pa, good gas permeability, and exceptional mechanical stability over 5000 compression cycles at high pressure. Benefiting from such excellent performances, a variety of fancy applications in detecting static pressure, including physiological signals, stealth transmission, the magnitude and spatial distribution of external tactile stimuli, as well as differentiating spatiotemporal tactile stimuli, are demonstrated. It is believed that stiffness engineering is a universal strategy for tailoring the performan...

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“…Soft bioelectronics have received numerous attention in diverse scenarios, such as health monitoring, − drug delivery, − human-machine interfaces, − and virtual reality/augmented reality applications, − due to their excellent mechanical, electrical, and biocompatible properties. Meanwhile, in order to meet the growing demands and expectations of digital health, emerging disruptive technologies have been utilized to develop advanced soft bioelectronics (e.g., wearable or implantable bioelectronics) to realize smart diagnosis of multiple diseases and disorders. − Compared with conventional electronics that are rigid, bulky, and planar, soft bioelectronics enable conformal and compliant attachment on soft, dynamically deformable, and curved irregular organs, such as skin, , brain, , heart, , and spinal cord. , So far, a broad spectrum of soft bioelectronics has been developed for precision diagnostics − by efficiently mining various physiological signals based on electrophysiological processes, − physical information, − and biochemical sensing. − …”

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confidence: 99%

Soft Bioelectronics for Therapeutics

Zhang,

Zhu,

Zhou

et al. 2023

ACS Nano

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Soft bioelectronics play an increasingly crucial role in high-precision therapeutics due to their softness, biocompatibility, clinical accuracy, long-term stability, and patient-friendliness. In this review, we provide a comprehensive overview of the latest representative therapeutic applications of advanced soft bioelectronics, ranging from wearable therapeutics for skin wounds, diabetes, ophthalmic diseases, muscle disorders, and other diseases to implantable therapeutics against complex diseases, such as cardiac arrhythmias, cancer, neurological diseases, and others. We also highlight key challenges and opportunities for future clinical translation and commercialization of soft therapeutic bioelectronics toward personalized medicine.

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Wireless, Skin‐Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring (Adv. Healthcare Mater. 17/2021)

Cited by 5 publications

References 0 publications

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Stiffness Engineering of Ti₃C₂T_X MXene‐Based Skin‐Inspired Pressure Sensor with Broad‐Range Ultrasensitivity, Low Detection Limit, and Gas Permeability

Soft Bioelectronics for Therapeutics

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Wireless, Skin‐Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring (Adv. Healthcare Mater. 17/2021)

Cited by 5 publications

References 0 publications

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Stiffness Engineering of Ti3C2TX MXene‐Based Skin‐Inspired Pressure Sensor with Broad‐Range Ultrasensitivity, Low Detection Limit, and Gas Permeability

Soft Bioelectronics for Therapeutics

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Product

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About

Stiffness Engineering of Ti₃C₂T_X MXene‐Based Skin‐Inspired Pressure Sensor with Broad‐Range Ultrasensitivity, Low Detection Limit, and Gas Permeability