Wireless transmission of ultrasonic waveforms for monitoring drug tablet properties and defects

Stephens, James D.; Lakshmaiah, M.V.; Kowalczyk, Brian R.; Hancock, Bruno C.; Cetinkaya, Çetin

doi:10.1016/j.ijpharm.2012.08.050

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…The ultrasonic method is also widely applied in the field of pharmaceutical research. Since ultrasonics use a mechanical wave, the speed of sound is sensitive to mechanical properties, and thus, it has been used to determine the porosity and elastic modulus of tablets and coating thickness [58,[68][69][70][71][72][73][74][75][76]. As an example, Figure 5 shows the wireless transmission of ultrasonic waveforms for monitoring drug tablet properties and defects as reported by Stephens et al [70].…”

Section: Application Examplesmentioning

confidence: 99%

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Stranzinger

Markl

Khinast

et al. 2021

TrAC Trends in Analytical Chemistry

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Section: Application Examplesmentioning

confidence: 99%

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Stranzinger

Markl

Khinast

et al. 2021

TrAC Trends in Analytical Chemistry

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“…Young's moduli of the compacts were extracted using data acquisition methods during the compaction and decompression processes. In a subsequent study, Stephens et al reported the use of wireless transceiver for analyzing of tablets' geometric and microstructural properties in real-time (Stephens et al, 2013a). Ultrasonic pulses were generated by a transducer fixed to the upper punch.…”

Section: Contact and Wireless Ultrasonic Testingmentioning

confidence: 99%

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

Dave

Shahin

Youngren-Ortiz³

et al. 2017

International Journal of Pharmaceutics

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The density, porosity, breaking force, viscoelastic properties, and the presence or absence of any structural defects or irregularities are important physical-mechanical quality attributes of popular solid dosage forms like tablets. The irregularities associated with these attributes may influence the drug product functionality. Thus, an accurate and efficient characterization of these properties is critical for successful development and manufacturing of a robust tablets. These properties are mainly analyzed and monitored with traditional pharmacopeial and non-pharmacopeial methods. Such methods are associated with several challenges such as lack of spatial resolution, efficiency, or sample-sparing attributes. Recent advances in technology, design, instrumentation, and software have led to the emergence of newer techniques for non-invasive characterization of physical-mechanical properties of tablets. These techniques include near infrared spectroscopy, Raman spectroscopy, X-ray microtomography, nuclear magnetic resonance (NMR) imaging, terahertz pulsed imaging, laser-induced breakdown spectroscopy, and various acoustic- and thermal-based techniques. Such state-of-the-art techniques are currently applied at various stages of development and manufacturing of tablets at industrial scale. Each technique has specific advantages or challenges with respect to operational efficiency and cost, compared to traditional analytical methods. Currently, most of these techniques are used as secondary analytical tools to support the traditional methods in characterizing or monitoring tablet quality attributes. Therefore, further development in the instrumentation and software, and studies on the applications are necessary for their adoption in routine analysis and monitoring of tablet physical-mechanical properties.

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“…Tracking fluctuations in these parameters would be important in demonstrating the consistency of the product during routine manufacture, and may even go some way to supporting real time release testing. Some studies investigate the use of ultrasonic wave for the real-time tablet inspection [12]. Although the information obtained probes deeper within the tablet surface, this approach has the disadvantage over the optical inspection systems in real-time applications where the tablets under inspection would be in motion and the speed of ultrasound is not as fast that that of light to achieve a pinpoint inspection.…”

Section: Introductionmentioning

confidence: 99%

Micro-Structural Analysis of Tablet Surface Layers by Intelligent Laser Speckle Classification (ILSC) Technique: an Application in the Study of both Surface Defects and Subsurface Granule Structures

Orun

Smith

2017

J Pharm Innov

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Purpose : As a consequence of the latest developments in laser technologies it is now possible to develop a low-cost and accurate tablet inspection system by the unification of optical and artificial intelligence methods. Method: The functionality of the proposed system is based on a sequence of texture analysis of laser speckle images (using laser sources of 650 nm and 808 nm : VIS/IR) followed by the optimization of texture parameters using Bayesian Networks (BN). Results: In the first part of this work, a Bayesian inference method was used to detect micro-scale tablet defects that are generated "progressively" during production whereas in the second part a Bayesian classifier method was used to discriminate between tablets made from different granule sizes. In part two, it was shown that (i) the comparatively higher energy (5mW) IR laser light generates different speckle effects than the lower energy visible (Red 3mW) by interacting with deeper sub-surface of the tablets and (ii) by using multiclassifier systems (MCS) to fuse the Bayesian classifiers from both types of speckle images it was possible to achieve a higher discrimination power (88% classification accuracy) for distinguishing between tablets made from different granule sizes than one can achieve from a single image type. Conclusion: It is suggested that this unified method has the potential to provide for a comprehensive analysis of both tablet quality attributes, on the one hand, and failure modes, on the other, that might be used in the development of a low cost tablet inspection system.

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Wireless transmission of ultrasonic waveforms for monitoring drug tablet properties and defects

Cited by 8 publications

References 12 publications

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

Micro-Structural Analysis of Tablet Surface Layers by Intelligent Laser Speckle Classification (ILSC) Technique: an Application in the Study of both Surface Defects and Subsurface Granule Structures

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