Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals

Zhao, Yu; Liu, Changbo; Liu, Zhixiang; Luo, Wenhan; Li, Lizhu; Xue, Chaoyang; Liang, Dong; Su, Yuanzhe; Ding, He; Wang, Qiang; Yin, Lan; Guan, Ji‐Song; Luo, Minmin; Sheng, Xing

doi:10.1109/ted.2018.2882397

Cited by 36 publications

(32 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under current injection, the peak wavelength for the LED emission is around 470 nm ( Fig. 2a), which matches to the optical absorption of commonly used opsins like ChR2 as optogenetic tools 13,[26][27][28] . The external quantum efficiency (EQE) for LEDs with and without diamond and PEDOT:PSS films are plotted in Fig.…”

Section: Optoelectronic and Thermal Propertiessupporting

confidence: 58%

“…Representative examples include our recently developed optoelectronic probes for wireless optogenetic stimulation and fluorescence recording in freely moving rodents [11][12][13][14][15] . Besides electrical pulses and calcium flows, neurotransmitters, which comprise a plethora of chemicals like dopamine, glutamate, serotonin, etc., are of critical importance and direct relevance in neural activities and brain functions 16,17 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection

Liu

Zhao

Xue

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Physical and chemical technologies have been continuously progressing advances of neuroscience research. The development of research tools for closed-loop control and monitoring neural activities in behaving animals is highly desirable. In this paper, we introduce a wirelessly operated, miniaturized microprobe system for optical interrogation and neurochemical sensing in the deep brain. Via epitaxial liftoff and transfer printing, microscale light emitting diodes (micro-LEDs) as light sources, and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) coated diamond films as electrochemical sensors are vertically assembled to form implantable optoelectrochemical probes, for real-time optogenetic stimulation and dopamine detection capabilities. A customized, lightweight circuit module is employed for untethered, remote signal control and data acquisition. Injected into the ventral tegmental area (VTA) of freely behaving mice, in vivo experiments clearly demonstrate the utilities of the multifunctional optoelectrochemical microprobe system for optogenetic interference of place preferences and detection of dopamine release. The presented options for material and device integrations provide a practical route to simultaneous optical control and electrochemical sensing of complex nervous systems.

show abstract

Section: Optoelectronic and Thermal Propertiessupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection

Liu

Zhao

Xue

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…[ 156,157 ] Recently developed transfer printing techniques [ 158 ] have allowed direct integration of microscale inorganic light‐emitting diodes (μ‐ILEDs) directly on soft polymer substrates for optogenetics. Combining μ‐ILEDs with wireless power‐harvesting modules such as head‐mounted batteries, [ 159–161 ] photovoltaic cells, [ 162–165 ] and alternative battery‐free energy harvesting techniques [ 166–168 ] has generated highly miniaturized wireless platforms suitable for use in freely moving small animals and complex 3D environments. Figure a shows the first wireless multimodal optogenetics probe that can induce place preference in freely moving mice through optically modulating anxiety‐like behaviors.…”

Section: Microsystems For Optical Biointerfacingmentioning

confidence: 99%

Advanced Electrical and Optical Microsystems for Biointerfacing

Obaid

Chen

2020

Advanced Intelligent Systems

View full text Add to dashboard Cite

Electrical and optical biointerfaces have contributed considerably to understanding biological systems. Recent advances in biocompatible materials, structure designs, and fabrication techniques have established flexible and minimally invasive electronic/optoelectronic platforms that laminate onto targeted surface regions or implant into precise locations of biosystems to monitor and control various biological processes at cell, tissue, and organ levels. Herein, recent progress in advanced biointegrated electrical and optical platforms is discussed. An overview of materials and device designs to form flexible and even stretchable electrodes is presented. Strategies to reduce tissue damage and foreign‐body response to improve chronic stability are described. State‐of‐the‐art wearable and implantable microsystems with/without wireless capabilities for bioelectrical sensing and stimulation, optical recording and modulation, and multimodal operation are highlighted. In conclusion, a discussion of the remaining obstacles for future research in these areas is provided.

show abstract

“…This technique provides optical, thermal, and electrophysiological studies in a freely moving environment. Yu [40] provided a wirelessly controlled, implantable, micro-LEDs based optical neural face for behaving animals, which is interesting for animal behavior research in neuroscience.…”

Section: B the Comparison To The Other Workmentioning

confidence: 99%

The Neural Engine: A Reprogrammable Low Power Platform for Closed-Loop Optogenetics

Luo

Firflionis

Turnbull

et al. 2020

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

Brain-machine Interfaces (BMI) hold great potential for treating neurological disorders such as epilepsy. Technological progress is allowing for a shift from open-loop, pacemaker-class, intervention towards fully closed-loop neural control systems. Low power programmable processing systems are therefore required which can operate within the thermal window of 2O C for medical implants and maintain long battery life. In this work, we have developed a low power neural engine with an optimized set of algorithms which can operate under a power cycling domain. We have integrated our system with a custom-designed brain implant chip and demonstrated the operational applicability to the closedloop modulating neural activities in in-vitro and in-vivo brain tissues: the local field potentials can be modulated at required central frequency ranges. Also, both a freely-moving non-human primate (24-hour) and a rodent (1-hour) in-vivo experiments were performed to show system reliable recording performance. The overall system consumes only 2.93mA during operation with a biological recording frequency 50Hz sampling rate (the lifespan is approximately 56 hours). A library of algorithms has been implemented in terms of detection, suppression and optical intervention to allow for exploratory applications in different neurological disorders. Thermal experiments demonstrated that operation creates minimal heating as well as battery performance exceeding 24 hours on a freely moving rodent. Therefore, this technology shows great capabilities for both neuroscience invitro/in-vivo applications and medical implantable processing units.

show abstract

Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals

Cited by 36 publications

References 31 publications

A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection

A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection

Advanced Electrical and Optical Microsystems for Biointerfacing

The Neural Engine: A Reprogrammable Low Power Platform for Closed-Loop Optogenetics

Contact Info

Product

Resources

About