A film stress measurement system applicable for hyperbaric environment was developed to characterize stress evolution in a physical simulation test of a gas-solid coupling geological disaster. It consists of flexible film pressure sensors, a signal conversion module, and a highly-integrated acquisition box which can perform synchronous and rapid acquisition of 1 kHz test data. Meanwhile, we adopted a feasible sealing technology and protection method to improve the survival rate of the sensors and the success rate of the test, which can ensure the accuracy of the test results. The stress measurement system performed well in a large-scale simulation test of coal and gas outburst that reproduced the outburst in the laboratory. The stress evolution of surrounding rock in front of the heading is completely recorded in a successful simulation of the outburst which is consistent with the previous empirical and theoretical analysis. The experiment verifies the feasibility of the stress measurement system as well as the sealing technology, laying a foundation for the physical simulation test of gas-solid coupled geological disasters.