Wiring of bilirubin oxidases with redox polymers on gas diffusion electrodes for increased stability of self-powered biofuel cells-based glucose sensing

Becker, Jana M; Lielpētere, Anna; Szczesny, Julian; Bichon, Sabrina; Gounel, Sébastien; Mano, Nicolas; Schuhmann, Wolfgang

doi:10.1016/j.bioelechem.2022.108314

Cited by 7 publications

(6 citation statements)

References 61 publications

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“…During recent years, many enzymatic biofuel cells have been designed to measure biological species that can also act as the biofuels. Table summarizes some of the recently reported self-powered enzymatic biosensors, where the analyte plays the role of biofuel simultaneously. ,− Self-powered enzymatic biosensors as green energy conversion devices have become a new research focus due to their efficient, simple, and biofriendly operation . They have an advantage of higher power density (1.65–4.1 mW cm –2 ) than other biofuel cells.…”

Section: Self-powered Bioelectrochemical Sensorsmentioning

confidence: 99%

Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications

Farzin,

Naghib,

Rabiee

2024

ACS Biomater. Sci. Eng.

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The rapid maturation of smart city ecosystems is intimately linked to advances in the Internet of Things (IoT) and self-powered sensing technologies. Central to this evolution are battery-less sensors that are critical for applications such as continuous health monitoring through blood metabolites and vital signs, the recognition of human activity for behavioral analysis, and the operational enhancement of humanoid robots. The focus on biosensors that exploit the human body for energy-spanning wearable, attachable, and implantable variants has intensified, driven by their broad applicability in areas from underwater exploration to biomedical assays and earthquake monitoring. The heart of these sensors lies in their diverse energy harvesting mechanisms, including biofuel cells, and piezoelectric, triboelectric, and pyroelectric nanogenerators. Notwithstanding the wealth of research, the literature still lacks a holistic review that integrates the design challenges and implementation intricacies of such sensors. Our review seeks to fill this gap by thoroughly evaluating energy harvesting strategies from both material and structural perspectives and assessing their roles in powering an array of sensors for myriad uses. This exploration offers a comprehensive outlook on the state of self-powered sensing devices, tackling the nuances of their deployment and highlighting their potential to revolutionize data gathering in autonomous systems. The intent of this review is to chart the current landscape and future prospects, providing a pivotal reference point for ongoing research and innovation in selfpowered wireless sensing technologies.

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Section: Self-powered Bioelectrochemical Sensorsmentioning

confidence: 99%

Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications

Farzin,

Naghib,

Rabiee

2024

ACS Biomater. Sci. Eng.

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“…The versatile applications of BOD enzyme-based cathodes in fuel cells span a range of fields, from biobattery, medical devices, and H 2 /O 2 fuel cells, to environmental monitoring, showcasing the enzyme’s potential impact in various technological developments. − Herein, we discussed an overview of BODs-based biocathodes in EFCs utilizing biomolecules for biosensors and powering bioelectronics. A redox polymer/BOD-based gas diffusion electrode has been reported as a noncurrent and nonstability-limiting biocathode in a glucose/O 2 biofuel cell . The biofuel cell was designed to function as a self-powered glucose biosensor.…”

Section: Biofuel Cells: Enzymatic Fuel Cellsmentioning

confidence: 99%

“…A redox polymer/BOD-based gas diffusion electrode has been reported as a noncurrent and nonstability-limiting biocathode in a glucose/O 2 biofuel cell. 100 The biofuel cell was designed to function as a self-powered glucose biosensor. The biocathode was responsible for the reduction of oxygen (O 2 ) to water (H 2 O) in the presence of electrons and protons.…”

Section: Biofuel Cells: Enzymatic Fuel Cellsmentioning

confidence: 99%

Emerging Trends of Bilirubin Oxidases at the Bioelectrochemical Interface: Paving the Way for Self-Powered Electrochemical Devices and Biosensors

Thangavel,

Venkatachalam,

Shin

2024

ACS Appl. Bio Mater.

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Bilirubin oxidases (BODs) are enzymes that belong to the multicopper oxidase family and can oxidize bilirubin, diphenols, and aryl amines and reduce the oxygen by direct fourelectron transfer from the electrode with almost no electrochemical overpotential. Therefore, BOD is a promising bioelectrocatalyst for (self-powered) biosensors and/or enzymatic fuel cells. The advantages of electrochemically active BOD enzymes include selective biosensing, biocatalysis for efficient energy conversion, and electrosynthesis. Owing to the rise in publications and patents, as well as the expanding interest in BODs for a range of physiological conditions, this Review analyzes scientific literature reports on BOD enzymes and current hypotheses on their bioelectrocatalysis. This Review evaluates the specific research outcomes of the BOD in enzyme (protein) engineering, immobilization strategies, and challenges along with their bioelectrochemical properties, limitations, and applications in the fields of (i) biosensors, (ii) self-powered biosensors, and (iii) biofuel cells for powering bioelectronics.

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“…Most of the developed glucose EBFCs and EBFC-based biosensors use two enzymes: the anode is modified with a glucose-oxidizing enzyme, and the cathode is modified with an oxygen-reducing enzyme [ 22 , 23 , 24 ]. Bi-enzymatic biocathodes, in which a hydrogen peroxide-reducing enzyme is combined with a glucose-oxidizing enzyme, have also been described [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Towards a Self-Powered Amperometric Glucose Biosensor Based on a Single-Enzyme Biofuel Cell

Kausaite-Minkstimiene,

Kaminskas,

Gayda

et al. 2024

Biosensors

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This paper describes the study of an amperometric glucose biosensor based on an enzymatic biofuel cell consisting of a bioanode and a biocathode modified with the same enzyme—glucose oxidase (GOx). A graphite rod electrode (GRE) was electrochemically modified with a layer of Prussian blue (PB) nanoparticles embedded in a poly(pyrrole-2-carboxylic acid) (PPCA) shell, and an additional layer of PPCA and was used as the cathode. A GRE modified with a nanocomposite composed of poly(1,10-phenanthroline-5,6-dione) (PPD) and gold nanoparticles (AuNPs) entrapped in a PPCA shell was used as an anode. Both electrodes were modified with GOx by covalently bonding the enzyme to the carboxyl groups of PPCA. The developed biosensor exhibited a wide linear range of 0.15–124.00 mM with an R2 of 0.9998 and a sensitivity of 0.16 μA/mM. The limit of detection (LOD) and quantification (LOQ) were found to be 0.07 and 0.23 mM, respectively. The biosensor demonstrated exceptional selectivity to glucose and operational stability throughout 35 days, as well as good reproducibility, repeatability, and anti-interference ability towards common interfering substances. The studies on human serum demonstrate the ability of the newly designed biosensor to determine glucose in complex real samples at clinically relevant concentrations.

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Wiring of bilirubin oxidases with redox polymers on gas diffusion electrodes for increased stability of self-powered biofuel cells-based glucose sensing

Cited by 7 publications

References 61 publications

Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications

Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications

Emerging Trends of Bilirubin Oxidases at the Bioelectrochemical Interface: Paving the Way for Self-Powered Electrochemical Devices and Biosensors

Towards a Self-Powered Amperometric Glucose Biosensor Based on a Single-Enzyme Biofuel Cell

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