Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems

Nomdedeu‐Sancho, Gemma; Alsina, Berta

doi:10.1002/dvdy.523

Cited by 7 publications

(6 citation statements)

References 212 publications

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“…Notably, for secreted signalings, Sema3 family, Wnt and Bmp sourced from olfactory epithelium showed a high communication probability to target olfactory sensory neurons (Fig. 6b), in line with their reported role in regulation of axon outgrowth and navigating of olfactory sensory neuron 52–56 . Visualization of Wnt4 and Fzd3 expression on the tissues showed a high co-expression level in the co-occurrent spots of olfactory epithelium and olfactory sensory neurons (Fig.…”

Section: Resultssupporting

confidence: 76%

Three-dimensional molecular architecture of mouse organogenesis

et al. 2022

Preprint

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Mammalian embryos have sophisticated cell organizations that are orchestrated by molecular regulation at cellular and tissue level. It has recently been appreciated that the cells that make up the animal body themselves harbor significant heterogeneity in the context of both cellular and particularly spatial dimension. However, current spatial transcriptomics profiling of embryonic tissues either lack three-dimensional representation or are restricted to limited depth and organs. Here, we reported a holistic spatial transcriptome atlas of all major organs at embryonic day 13.5 of mouse embryo and delineated a 3D rendering of the molecular regulation of embryonic patterning. By integrating with corresponding single-cell transcriptome data, the spatial organogenesis atlas provides rich molecular annotation of the dynamic organ nature, spatial cellular interaction, embryonic axes and divergence of cell fates underlying mammalian development, which would pave the way for precise organ-engineering and stem-cell based regenerative medicine.

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Section: Resultssupporting

confidence: 76%

Three-dimensional molecular architecture of mouse organogenesis

et al. 2022

Preprint

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“…[ 105 ]). In contrast, only neurons are generated from epibranchial placodes [ 16 , 126 ]. Specifically, the facial (VII), glossopharyngeal (IX) and vagal (X) neurons develop from placodal and neural crest cells [ 127 ].…”

Section: Development Of Distinct Placodal Derivatives Of the Otic Pla...mentioning

confidence: 99%

“…Induction of the epibranchial placodes depend critically on the expression of Eya1/2/Six1/4 . These genes are upstream of Pax2 , which help define the caudal ( Pax2/8 , VII, IX, X) placodes [ 75 , 126 ]. Additional genes are important in the development of the placodes contributing to the different cranial ganglia.…”

Section: Development Of Distinct Placodal Derivatives Of the Otic Pla...mentioning

confidence: 99%

“…In the absence of Foxi3 expression, the ectoderm fails to thicken, and all placodes fail to form [ 48 ]. Six1/2/4 and Eya1/2 are essential for the specific formation of epibranchial placodes [ 33 , 72 , 126 ] downstream of Foxi3. The Sox2 , which is ubiquitously expressed in the epibranchial placodes, is required for neuron development [ 108 ].…”

Section: Development Of Neuronal Genes Are Needed For Ears and Epibra...mentioning

confidence: 99%

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Early Steps towards Hearing: Placodes and Sensory Development

Zine

Fritzsch

2023

IJMS

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Sensorineural hearing loss is the most prevalent sensory deficit in humans. Most cases of hearing loss are due to the degeneration of key structures of the sensory pathway in the cochlea, such as the sensory hair cells, the primary auditory neurons, and their synaptic connection to the hair cells. Different cell-based strategies to replace damaged inner ear neurosensory tissue aiming at the restoration of regeneration or functional recovery are currently the subject of intensive research. Most of these cell-based treatment approaches require experimental in vitro models that rely on a fine understanding of the earliest morphogenetic steps that underlie the in vivo development of the inner ear since its initial induction from a common otic–epibranchial territory. This knowledge will be applied to various proposed experimental cell replacement strategies to either address the feasibility or identify novel therapeutic options for sensorineural hearing loss. In this review, we describe how ear and epibranchial placode development can be recapitulated by focusing on the cellular transformations that occur as the inner ear is converted from a thickening of the surface ectoderm next to the hindbrain known as the otic placode to an otocyst embedded in the head mesenchyme. Finally, we will highlight otic and epibranchial placode development and morphogenetic events towards progenitors of the inner ear and their neurosensory cell derivatives.

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“…This enables a broad diversification of function as similar guidance cues can be used in distinct combinations to promote alternative outcomes. Nomdedeu‐Sancho and Alsina 3 review these principles in the context of afferent neurons innervating sensory organs of the head. Thus, even sensory neurons with common origins such as the auditory and vestibular neurons of the inner ear can innervate distinct populations of sensory hair cells.…”

mentioning

confidence: 99%