Wirksamkeit der Behandlung mit Repithel®und Jelonet®im Vergleich zur alleinigen Anwendung von Jelonet®- eine randomisierte klinische Studie an Meshgraft-Transplantationswunden

Hauser, Jörg; Roßbach, O.; Pm, Vogt; Reimer, Karen; Bosse, B.; Fleischer, Wolfgang; Hu, Steinau

doi:10.1055/s-2006-933479

Cited by 7 publications

(1 citation statement)

References 16 publications

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“…However, the beneficial effects of liposomal PVP-iodine hydrogel in complex skin conditions were demonstrated in a study of split-thickness skin grafts which represent different skin depths likely present in patients in the present study. 62 …”

Section: Discussionmentioning

confidence: 99%

Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study

Augustin¹,

Goepel²,

Jacobi³

et al. 2017

CCID

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Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. In this prospective, single-arm (uncontrolled), open-label Phase II pilot study, patients with acne vulgaris (n=30), atopic dermatitis (n=20), impetigo contagiosa (n=10), and rosacea (n=10) received PVP-iodine (3%) hydrogel for ≤4 weeks. Global Clinical Severity score improved for all dermatoses (range: 0.5 for acne vulgaris [p<0.001] to 1.0 for impetigo contagiosa [p=0.011]). Improvements in pain, quality of life, (Freiburg Life Quality Assessment), and Eczema Area and Severity Index scores were also seen. Treatment was well tolerated; most frequent adverse events were burning (14%) or itching (9%) sensations. Thus, liposomal PVP-iodine hydrogel has potential utility as an effective treatment for inflammatory skin conditions associated with bacterial colonization.

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Section: Discussionmentioning

confidence: 99%