Wirksamkeit, Moderatoren und Mediatoren manualisierter
                    familienbasierter Therapie bei Jugendlichen mit Essstörungen: Eine
                    systematische Übersichtsarbeit

Schlegl, Sandra; Voderholzer, Ulrich; Maier, Julia; Naab, Silke; Lock, James

doi:10.1055/a-0977-3413

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…"nicht mitreden" könnten. Diese Haltung steht im Gegensatz zu den Behandlungsprinzipien der in England und den USA weiterentwickelten Family-Based Therapy, die die Eltern als aktive Kotherapeuten mit einbezieht und die in Deutschland zunehmend mehr Anhänger findet [31].…”

Section: Home-treatment Bei Anunclassified

Anorexia nervosa – eine metabolisch-psychiatrische Erkrankung?

Herpertz‐Dahlmann¹,

Seitz²,

Dahmen³

2022

Nervenheilkunde

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ZUSAMMENFASSUNGDie Anorexia nervosa (AN) ist die psychische Erkrankung mit der höchsten Mortalität. Individuen, die im Jugendalter erkranken, leiden durchschnittlich über 10 Jahre an dieser Störung. Obwohl die klinische Erfahrung und internationale sowie nationale Studien auf einen unzureichenden Heilungserfolg hinweisen, wird in Deutschland meist an der traditionellen langdauernden stationären Behandlung festgehalten. Studien zur Erforschung der Ätiologie haben neue Erkenntnisse gebracht. Der vorliegende Artikel will beispielhaft neue biologische und psychologische Interventionen aufzeigen, die die Prognose dieser Erkrankung verbessern könnten. Dazu gehören therapeutische Strategien, die auf das Darm-Mikrobiom und damit auf die Darm-Gehirn-Achse Einfluss nehmen, eine neue experimentelle Behandlung mit Metreleptin (rekombinantes menschliches Leptin) sowie ein neues Behandlungssetting, das Home-Treatment. Nach erfolgreichen Pilotstudien soll in randomisiert-kontrollierten Studien herausgefunden werden, wie eine „personalisierte Behandlung“ der AN in Abhängigkeit von Schweregrad und Krankheitsdauer durchgeführt werden könnte.

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Section: Home-treatment Bei Anunclassified

Anorexia nervosa – eine metabolisch-psychiatrische Erkrankung?

Herpertz‐Dahlmann¹,

Seitz²,

Dahmen³

2022

Nervenheilkunde

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“…Over the past three decades, research on eating disorders (EDs) including anorexia nervosa (AN) has explored a variety of psychological as well as pharmacological strategies to enhance outcomes in the hopes of improving well‐recognized challenges with modest response rates for evidence‐based treatments (de Rijk et al, 2023; Fornaro et al, 2023; Zhu et al, 2023; Monteleone et al, 2022; Steinhausen, 2009). Despite best efforts to optimize treatment success, AN has the continued undesirable distinction of having the highest mortality rate of all psychiatric disorders (Arcelus et al, 2011), while reviews suggests that only half of youth remit after gold‐standard treatments such as manualized family based therapy are received (Schlegl et al, 2020; Touyz et al, 2023). While benefits of manualized treatments are numerous, and include the use of evidence‐based treatments, facilitation of research, training, treatment dissemination, and treatment fidelity using structured and standardized protocols that can be tested and evaluated, limitations are also abundant.…”

Section: Introductionmentioning

confidence: 99%

“…psychiatric disorders (Arcelus et al, 2011), while reviews suggests that only half of youth remit after gold-standard treatments such as manualized family based therapy are received (Schlegl et al, 2020;Touyz et al, 2023). While benefits of manualized treatments are numerous, and include the use of evidence-based treatments, facilitation of research, training, treatment dissemination, and treatment fidelity using structured and standardized protocols that can be tested and evaluated, limitations are also abundant.…”

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confidence: 99%

Pragmatic clinical trials to advance research in children and adolescents with eating disorders

Norris,

Spettigue,

Obeid

2024

Intl J Eating Disorders

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ObjectiveTo discuss the utility of pragmatic clinical trials (PCTs) to help advance research in eating disorders (EDs).MethodsWe describe challenges associated with traditional explanatory research trials and examine PCTs as an alternative, including a review of the PRECIS‐2 tool.ResultsThere are many challenges associated with the design and completion of traditional RCTs within the field of EDs. Pragmatic clinical trials are studies that closely align with conditions available in everyday practice and focus on outcomes that are relevant to patients and clinicians. Results of PCTS maximize applicability and generalizability to clinical settings.DiscussionAvailable therapies established for the treatment of EDs provide remission rates that rarely exceed 50%, implying a need for additional research on new or adjunctive treatments. In addition to a general overview of PCTs, we draw upon published literature and our own experiences involving adjunctive olanzapine for the treatment of children and youth with anorexia nervosa to help highlight challenges associated with randomized controlled trial (RCT) design and implementation, and offer pragmatic suggestions that would allow patients greater choice in treatment trials, while at the same time capturing outcomes that are most likely to advance treatment efforts.ConclusionsPragmatic clinical trials provide alternatives to RCT design that can help bolster research in EDs that aims to explore real‐world effects of interventions.Public SignificanceAvailable therapies established for the treatment of eating disorders (EDs) in children and adolescents provide remission rates that rarely exceed 50%, implying a need for additional research on new or adjunctive treatments. In this article, we discuss the utility of pragmatic trials to help promote research that can help advance knowledge that is relevant to clinical care settings.

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Familienbasierte Therapie

Naab¹

2022

Handbuch Essstörungen Und Adipositas

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Wirksamkeit, Moderatoren und Mediatoren manualisierter familienbasierter Therapie bei Jugendlichen mit Essstörungen: Eine systematische Übersichtsarbeit

Cited by 4 publications

References 62 publications

Anorexia nervosa – eine metabolisch-psychiatrische Erkrankung?

Anorexia nervosa – eine metabolisch-psychiatrische Erkrankung?

Pragmatic clinical trials to advance research in children and adolescents with eating disorders

Familienbasierte Therapie

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