Wirus Epsteina-Barr w wybranych chorobach nowotworowych

Koleśnik, Marcin; Dworzańska, Anna; Polz‐Dacewicz, Małgorzata

doi:10.18388/pb.2020_364

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Współcześnie, aby wirus lub inny czynnik zakaźny, został zaliczony do grona onkogenów musi istnieć związek przyczynowy między guzem (chorobą) a pojawieniem wirusa, oraz potwierdzona obecność antygenu lub genomu wirusa w komórkach nowotworowych. Wirus wyizolowany z tkanki nowotworowej powinien transformować komórki w warunkach in vitro (7). Historyczne i współczesne kryteria są zbieżne -,,potwierdzenie obecności tworów żywych" to znalezienie materiału genetycznego wirusa w komórkach nowotworowych.…”

Section: Methodsunclassified

“…Nowadays, for a virus or other infectious agent to be counted as an oncogene, there must be a causal relationship between the tumor (disease) and the appearance of a virus, and the confirmed presence of antigen or viral genome in tumor cells. A virus isolated from tumor tissue should transform cells in vitro (7). Historical and modern criteria coincide -"confirmation of the presence of viable organisms" is to find the genetic material of virus in tumor cells.…”

Section: Introductionmentioning

confidence: 99%

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Theory on the infectious and parasitic origin of malignant diseases with reference to the polish scholars’ papers – historical essay

Paliga

2022

Przegl Epidemiol

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The theory about the infectious causes of cancer was very popular at the turn of the nineteenth and twentieth centuries. The research methodology to confirm this hypothesis was based on diagnostic methods used by bacteriology. Various types of experiments were carried out on animals and humans. Attempts were made to “infect” cancer, as well as to transplant cancer cells into healthy animals. Disinfectants were studied looking for opportunities for anti-cancer prophylaxis. They were guided by analogy and empiricism, clinical images of diseases were compared. The aim of the article is to recall research on the infectious theory of cancer with a reminder of the achievements of Polish scientists in this field, and to try to determine the genesis of this theory.

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Section: Methodsunclassified

Section: Introductionmentioning

confidence: 99%

Theory on the infectious and parasitic origin of malignant diseases with reference to the polish scholars’ papers – historical essay

Paliga

2022

Przegl Epidemiol

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“…The Epstein Barr virus (EBV) is historically the first virus in which an miRNA was discovered [46]. This doublestranded herpes virus infects about 90% of people worldwide, and is found in all major types of lymphoma [47,48]. EBV is detected in approximately 15% of diffuse large-B-cell lymphoma (DLBCL) cases [49].…”

Section: Mirna In Ebv and Hpv-associated Cancersmentioning

confidence: 99%

The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers

Koleśnik¹,

Stępień²,

Polz‐Dacewicz³

2021

J Pre Clin Clin Res.

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Introduction and objective. Biomarkers are measurable biological indicators of many disease states. Particularly noteworthy are short nucleotide sequences involved in the regulation of many cellular processes. Their level in body fluids constitutes an important biological marker of serious diseases, such as cancer or cardiovascular diseases. For example, different types of microRNA may be used as biomarker in virus-associated cancers. The aim of this article was to review the current knowledge on the miRNAs and their role in viral-related cancers (EBV and HPV). The article reviews information available in journals and on electronic databases. Brief description of the state of knowledge. A significant part of the world's population hosts at least one of the oncoviruses, but only a small percentage of them undergo a cancerogenesis to which these infectious agents contribute. Interaction between the host cell and viral factors can lead to the origination of a microenvironment favourable to oncogenesis. Cancer arises as a result of dysregulation in many cellular processes, and particularly important are short RNA sequences which regulate the processes that can cause this disease. The varied expression of this ribonucleic acid contributes to many diseases and provides valuable information about health. Importantly, these molecules are differentially expressed in virally-induced cancer. Many publications have confirmed the relationship between the expression of specific types of miRNA and cancers associated with EBV and HPV. Conclusions. The use of miRNAs as biomarkers of neoplastic diseases associated with EBV and HPV infections may significantly contribute to the reduction of mortality caused by these viruses, and thanks to the development of modern technologies they are an attractive research object.

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“…EBV belongs to the herpes family of viruses and is one of the most prevalent human viruses that spreads through body fluids, mainly saliva. EBV infects both epithelial and lymphoid cells and is associated with various cancers such as lymphomas or head and neck cancer [1,2,3,4]. One of the neoplasms located in the area of the head and neck is oropharyngeal cancer, the vast majority of which is squamous cell carcinoma [5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

MiRNA-21–5p as a biomarker in EBV-associated oropharyngeal cancer

Koleśnik¹,

Malm²,

Drop³

et al. 2022

Ann Agric Environ Med.

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Introduction and objective. Epstein-Barr virus (EBV) is associated with cancers of the head and neck, including oropharyngeal cancer, which is increasing in incidence, and biomarker studies have potential in diagnostics and therapy. One of the most commonly deregulated microRNAs in cancers is miR-21-5p. It has been implicated in neoplastic transformation related to EBV infection in several investigations. The aim of this study was to determine the level of miR-21-5p in the serum of EBV (+) and EBV (-) oropharyngeal cancer patients. Material and methods. The study was carried out on 78 patients with confirmed OPSCC. Statistical analysis was used to investigate the relationship between clinical and demographic characteristics of patients. Enzyme immunoassays were used to determine the levels of miRNA, TLR9 and MMPs and cytokines. Statistical analysis was used to determine the relationship between miR21-5p and TLR9, MMP3, MMP9 levels, and the cytokines studied. Results. Significantly higher values of all tested parameters for miR-21-5p levels and grading as well as TN stage were found in the EBV (+) group. There was no statistically significant correlation between the miR-21-5p level and the levels of TNFα, VEGF, and TGFβ. Positive correlations were shown between miR-21-5p and IL-10, MMP-3 and -9. There was a negative correlation between the level of miR-21-5p and TLR9. Conclusions. The present study showed that in EBV (+) patients the level of miR-21-5p in the serum was significantly higher than in EBV (-) patients. Our study results could influence future strategies for the diagnosis, prevention and treatment of oropharyngeal cancers.

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Wirus Epsteina-Barr w wybranych chorobach nowotworowych

Cited by 4 publications

References 34 publications

Theory on the infectious and parasitic origin of malignant diseases with reference to the polish scholars’ papers – historical essay

Theory on the infectious and parasitic origin of malignant diseases with reference to the polish scholars’ papers – historical essay

The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers

MiRNA-21–5p as a biomarker in EBV-associated oropharyngeal cancer

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