With a good quality blastocyst, single embryo transfer remains the best choice

Mancuso, Abigail C.; Kapfhamer, J.D.

doi:10.1016/j.fertnstert.2018.06.024

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…The goal of assist reproductive technology is to achieve a healthy singleton birth and minimize maternal and neonatal risk [1,2]. In order to realize the goal, elective single blastocyst transfer (eSBT) was preferred during these decades [3,4].…”

Section: Introductionmentioning

confidence: 99%

Cytoplasmic String Between ICM and mTE Is a Positive Predictor of Clinical Pregnancy and Live Birth Outcomes in Elective Frozen-thawed Single Blastocyst Transfer Cycles: a Time-lapse Study

Ma¹,

Jin²,

Huang³

2020

Preprint

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Background: In this study, we aim to investigate whether cytoplasmic string between inner cell mass (ICM) and mural trophectoderm (mTE) is a positive predictor of clinical pregnancy and live birth outcomes.Methods: 1,267 elective frozen-thawed single blastocyst transfer (eSBT) cycles cultured in time-lapse incubation system from January 2018 to May 2019 were involved in the study. Blastocysts were grouped according to the appearance of cytoplasmic strings between ICM and mTE cells, and identified as “Present” and “Absent” groups. In Present group, they were further categorized according to the quantity of cytoplasmic strings between ICM and mTE cells. Clinical pregnancy and live birth outcomes of blastocysts were used to evaluate the effect of cytoplasmic strings between ICM and mTE.Results: The baseline demographic and laboratory features were similar between the Present and Absent groups of cytoplasmic strings between ICM and mTE (P>0.05). According to the time-lapse analysis, cytoplasmic strings between ICM and mTE were more visible among good quality blastocysts. Furthermore, blastocysts with cytoplasmic strings showed a higher clinical pregnancy and live birth rates (P<0.05), and no significant differences were observed in abortion rate and birth weight (P>0.05).Conclusions: Although the previous conclusions of cytoplasmic strings were controversial, the present time-lapse analysis provides the evidence for the first time that cytoplasmic strings between ICM and mTE cells would be a positive predictor of clinical pregnancy and live birth outcomes in elective frozen-thawed single blastocyst transfer cycles.

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Section: Introductionmentioning

confidence: 99%

Cytoplasmic String Between ICM and mTE Is a Positive Predictor of Clinical Pregnancy and Live Birth Outcomes in Elective Frozen-thawed Single Blastocyst Transfer Cycles: a Time-lapse Study

Ma¹,

Jin²,

Huang³

2020

Preprint

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“…An explanation for these findings may be that blastocysts undergo a re-selection procedure that spans the 8-cell-stage developmental block and eliminates embryos with poor developmental potential compared to cleavage embryos (52-54). Moreover, this study found that a stable clinical pregnancy may have no correlation with the number of goodquality embryos, indicating the feasibility of single blastocyst transfer, effectively reducing the incidence of ovarian hyper stimulation syndrome, multiple birth rates, and fetal and maternal risks while ensuring relatively higher pregnancy and live birth rates (55)(56)(57). In addition, the current trend in assisted reproduction may become a more feasible approach in extending the duration of in vitro embryo culture to obtain more developed embryos, determining the implantation window for these mature embryos, and further improving the success rate of assisted reproduction (29).…”

Section: Discussionmentioning

confidence: 93%

Association between duration of progesterone supplementation and clinical outcomes in artificial frozen-thawed embryo transfer cycles

Liu¹,

Zhou²,

Hu³

et al. 2023

Front. Endocrinol.

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ObjectiveThe administration of progesterone before transfer in hormone replacement treatment (HRT) is crucial for the clinical outcomes of frozen-thawed embryo transfer (FET), but the optimal duration of progesterone remains controversial. This study aimed to investigate the effect of the duration of progesterone administration on the clinical outcomes of FET cycles.MethodsThis prospective cohort study included 353 artificial FET cycles conducted at a reproductive medicine center between April and October 2021. The FET cycles were stratified into four groups based on the duration of progesterone supplementation before the procedure and the embryonic development stage: group P3 (73 patients) received intramuscular progesterone for 3 days and group P4 (87 patients) for 4 days before Day 3 frozen embryo transfer, group P5 (70 patients) for 5 days and group P6 (123 patients) for 6 days before frozen blastocyst transfer. This trial was performed using one or two vitrified embryo(s) when the endometrial thickness reached 7 mm after estrogen supplementation in an artificial cycle. The primary outcome was clinical pregnancy, and secondary outcomes included biochemical pregnancy, implantation, early pregnancy loss, and live births.ResultsThere were no significant differences in the demographic and clinical characteristics between the groups. No significant difference was observed in the clinical pregnancy rates between groups: 23/73 (31.5%) in group P3 vs 28/87 (32.2%) in group P4 (P = 0.927). Compared to group P5 (41/70, 58.6%), the clinical pregnancy rate was not significantly different in group P6 (77/123, 62.6%, P = 0.753). There was no significant difference in the implantation rates between groups: 33/136 (24.3%) in group P3 vs 34/166 (20.5%) in group P4 (P = 0.431), and 62/133 (46.6%) in group P5 vs 107/231 (46.3%) in group P6 (P = 0.956). The duration of progesterone supplementation (mean: 3.5 ± 0.5 days; range:3–4 days) before Day 3 frozen embryo transfer did not impact clinical pregnancy (odds ratio [OR] 1.048; 95% confidence interval [CI], 0.518–2.119). The duration of progesterone administration (mean: 5.6 ± 0.5 days; range:5–6 days) before frozen blastocyst transfer may not affect clinical pregnancy (OR 1.339; 95% CI, 0.717–2.497).ConclusionThere may be no significant correlation between the duration of progesterone supplementation and pregnancy outcomes in artificial FET cycles, although the clinical pregnancy rate was higher when progesterone supplementation was extended for one day before FET.

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“…The goal of assisted reproductive technology is to achieve a healthy singleton birth and minimize maternal and neonatal risk ( 1 – 3 ). In order to realize this goal, elective single blastocyst transfer (eSBT) has been preferred in recent decades ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Cytoplasmic strings between ICM and mTE are a positive predictor of clinical pregnancy and live birth outcomes: A time-lapse study

Yang

Tian

et al. 2022

Front. Med.

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BackgroundElective single blastocyst transfer (eSBT) is considered to reduce the incidence of multiple pregnancy compared to double embryo transfer. Blastocyst selection is the key to achieving pregnancy. In the past, morphological assessment was the main criterion used to select blastocyst. Some important morphological parameters are considered to be clinically valuable, such as cytoplasmic strings traversing from the inner cell mass (ICM) and mural trophectoderm (mTE).MethodsIn this study, 1,267 elective frozen-thawed eSBT cycles cultured in a time-lapse culture system from January 2018 to May 2019 were included. Blastocysts were grouped into “present” and “absent” according to the appearance of cytoplasmic strings between ICM and mTE cells. The “present” group was further categorized according to the quantity of cytoplasmic strings between the ICM and mTE cells.ResultsA time-lapse analysis indicated that cytoplasmic strings between ICM and mTE were more visible among good quality blastocysts. Furthermore, blastocysts with cytoplasmic strings showed higher clinical pregnancy and live birth rates (P = 0.011 and 0.003), while no significant differences were observed in abortion rate and birth weight (P = 0.466 and 0.556).ConclusionsIn conclusion, although the results of previous studies about cytoplasmic strings have been controversial, the present time-lapse analysis provides evidence for the first time that cytoplasmic strings between ICM and mTE cells are a positive predictor of clinical pregnancy and live birth outcomes in elective frozen-thawed single blastocyst transfer cycles.

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With a good quality blastocyst, single embryo transfer remains the best choice

Cited by 8 publications

References 5 publications

Cytoplasmic String Between ICM and mTE Is a Positive Predictor of Clinical Pregnancy and Live Birth Outcomes in Elective Frozen-thawed Single Blastocyst Transfer Cycles: a Time-lapse Study

Cytoplasmic String Between ICM and mTE Is a Positive Predictor of Clinical Pregnancy and Live Birth Outcomes in Elective Frozen-thawed Single Blastocyst Transfer Cycles: a Time-lapse Study

Association between duration of progesterone supplementation and clinical outcomes in artificial frozen-thawed embryo transfer cycles

Cytoplasmic strings between ICM and mTE are a positive predictor of clinical pregnancy and live birth outcomes: A time-lapse study

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