Withania somnifera (L.) Dunal - Modern perspectives of an ancient Rasayana from Ayurveda

Mukherjee, Pulok K.; Banerjee, Subhadip; Biswas, Sayan; Das, Bhaskar; Kar, Amit; Katiyar, Chandra Kant

doi:10.1016/j.jep.2020.113157

Cited by 95 publications

(59 citation statements)

References 58 publications

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“…Notable examples include solanine, scopolamine, nicotine, atropine, capsaicin, and withanolides ( Balunas and Kinghorn, 2005 , Choi et al, 2006 ). Withania somnifera (also known as Ashwagandha, Indian ginseng, or winter cherry) is a medicinal plant of the Solanaceae family that has been in use for thousands of years in India and its neighboring counties ( Mukherjee et al, 2021 ). Extracts of Ashwagandha are utilized for remedies against inflammation, arthritis, diabetes, stress, asthma, and hypertension ( Widodo et al, 2010 , Widodo et al, 2007 , Mishra et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha)

Siddiqui

Ahmed

Goswami

et al. 2021

Current Research in Toxicology

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Section: Introductionmentioning

confidence: 99%

DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha)

Siddiqui

Ahmed

Goswami

et al. 2021

Current Research in Toxicology

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“…It has been used for centuries for various purposes in Ayurveda, the traditional system of medicine in India. It is an evergreen, straight, branching shrub that originates in Western India and Mediterranean regions [30]. The roots of plants are considered the most important part of the whole plant, as they are rich in bioactive molecule, especially withanolides, which is responsible for their medicinal property [31].…”

Section: Introductionmentioning

confidence: 99%

“…There is an increase in demand in Ashwagandha in the form of dietary supplements. Ashwagandha extracts from its root, leaves or combination of two is marketed in many forms, but pills and capsules are the commonest [30]. Researches have shown that it possesses antiinflammatory, anti-cancer, anti-stress, anti-oxidant, immunomodulatory, hemopoietic and rejuvenating properties [33,34].…”

Section: Introductionmentioning

confidence: 99%

Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis

et al. 2021

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Objective To determine the effect of Ashwagandha extract on sleep. Methods A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUSH Research Portal for all appropriate trials. Randomized controlled trials that examined the effect of Ashwagandha extract versus placebo on sleep in human participants 18 years old and above were considered. Two authors independently read all trials and independently extracted all relevant data. The primary outcomes were sleep quantity and sleep quality. The secondary outcomes were mental alertness on rising, anxiety level, and quality of life. Results A total of five randomized controlled trials containing 400 participants were analyzed. Ashwagandha extract exhibited a small but significant effect on overall sleep (Standardized Mean Difference -0.59; 95% Confidence Interval -0.75 to -0.42; I2 = 62%). The effects on sleep were more prominent in the subgroup of adults diagnosed with insomnia, treatment dosage ≥600 mg/day, and treatment duration ≥8 weeks. Ashwagandha extract was also found to improve mental alertness on rising and anxiety level, but no significant effect on quality of life. No serious side effects were reported. Conclusion Ashwagandha extract appears to has a beneficial effect in improving sleep in adults. However, data on the serious adverse effects of Ashwagandha extract are limited, and more safety data would be needed to assess whether it would be safe for long-term use.

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“…W. somnifera , more commonly known as ashwagandha, winter cherry, Indian ginseng and asgand [ 17 , 18 , 19 ], is a small woody shrub used for its medicinal properties in several traditional healing systems including Ayurveda, Unani and Siddha [ 17 , 18 , 20 ]. The dried roots of the plant are mainly employed in treatment, but the leaves, flowers and seeds are also utilized to a lesser extent [ 17 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress

et al. 2022

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Due to an increase in the aging population, age-related diseases and age-related changes, such as diminished cognition and sleep disturbances, are an increasing health threat. It has been suggested that an increase in oxidative stress underlies many of these changes. Current treatments for these diseases and changes either have low efficacy or have deleterious side effects preventing long-time use. Therefore, alternative treatments that promote healthy aging and provide resilience against these health threats are needed. The herbs Withania somnifera and Centella asiatica may be two such alternatives because both have been connected with reducing oxidative stress and could therefore ameliorate age-related impairments. To test the effects of these herbs on behavioral phenotypes induced by oxidative stress, we used the Drosophila melanogaster sniffer mutant which has high levels of oxidative stress due to reduced carbonyl reductase activity. Effects on cognition and mobility were assessed using phototaxis assays and both, W. somnifera and C. asiatica water extracts improved phototaxis in sniffer mutants. In addition, W. somnifera improved nighttime sleep in male and female sniffer flies and promoted a less fragmented sleep pattern in male sniffer flies. This suggests that W. somnifera and C. asiatica can ameliorate oxidative stress-related changes in behavior and that by doing so they might promote healthy aging in humans.

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Withania somnifera (L.) Dunal - Modern perspectives of an ancient Rasayana from Ayurveda

Cited by 95 publications

References 58 publications

DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha)

DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha)

Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis

Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress

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