Withanolides and Related Steroids

Misico, Rosana I.; Nicotra, Viviana E.; Oberti, Juan C.; Barboza, Gloria Estela; Gil, Roberto R.; Burton, Gerardo

doi:10.1007/978-3-7091-0748-5_3

Cited by 80 publications

(97 citation statements)

References 246 publications

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“…Among these, 20-Hydroxyecdysone is the primary bioactive constituent in A. bracteosa extract and is reported as anti-microbial, antitumor, anti-inflammatory and insect anti-feedant agent (Dinan 2001). Withanolides have proven to be effective in treatment against bronchial asthma, inflammation, cancer, and autoimmune diseases (Misico et al 2011). In the past decade, the market demand for A. bracteosa has increased dramatically not only in the subcontinent region but also in other Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Impacts of methyl jasmonate and phenyl acetic acid on biomass accumulation and antioxidant potential in adventitious roots of Ajuga bracteosa Wall ex Benth., a high valued endangered medicinal plant

Saeed

Ali

Khan

et al. 2017

Physiol Mol Biol Plants

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Ajuga bracteosa is a medicinally important plant globally used in the folk medicine against many serious ailments. In the present study, effects of two significant elicitors, methyl jasmonate (Me-J) and phenyl acetic acid (PAA) were studied on growth parameters, secondary metabolites production, and antioxidant potential in adventitious root suspension cultures of A. bracteosa. The results showed a substantial increase in biomass accumulation, exhibiting longer log phases of cultures growth in response to elicitor treatments, in comparison to control. Maximum dry biomass formation (8.88 DW g/L) was recorded on 32nd day in log phase of culture when 0.6 mg/L Me-J was applied; however, PAA at 1.2 mg/L produced maximum biomass (8.24 DW g/L) on day 40 of culture. Furthermore, we observed the elicitors-induced enhancement in phenolic content (total phenolic content), flavonoid content (total flavonoid content) and antioxidant activity (free radical scavenging activity) in root suspension cultures of A. bracteosa. Application of 0.6 mg/L and 1.2 mg/L of Me-J, root cultures accumulated higher TPC levels (3.6 mg GAE/g DW) and (3.7 mg GAE/g DW) in the log phase and stationary phase, respectively, while 2.5 mg/L Me-J produced lower levels (1.4 mg GAE/g DW) in stationary phase of growth stages. Moreover, TFC and FRSA values were found in correspondence to TPC values in the respective growth phases at the similar elicitor treatment. Thus, a feasible protocol for establishment of adventitious roots in A. bracteosa was developed and enhancement in biomass and metabolite content in adventitious root was promoted through elicitation.

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Section: Introductionmentioning

confidence: 99%

Impacts of methyl jasmonate and phenyl acetic acid on biomass accumulation and antioxidant potential in adventitious roots of Ajuga bracteosa Wall ex Benth., a high valued endangered medicinal plant

Saeed

Ali

Khan

et al. 2017

Physiol Mol Biol Plants

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“…The withanolides are ergostanolides which are chemically characterised by γ-or δ-lactone-containing side chain at C-17. They have previously been reported from Solanaceae (Glotter et al 1978;Fang et al 2013;Murthy & Praveen 2013;Khan et al 2015), Taccaceae (Chen et al 1988;Yang et al 2011), leguminosae (Srivastava et al 1992), lamiaceae, Myrtaceae (Chen et al 2011, Dioscoreaceae (Misico et al 2011;Ni et al 2015) families and marine organisms (Ksebati & Schmitz 1988). Withanolides have various biological activities such as antitumour/anticancer, antimicrobial, anti-inflammatory, cytotoxic, hepatoprotective, antioxidant, immunosuppressive (Ray & Gupta 1994), immunostimulation (Kushwaha et al 2012), antileukaemic agent (Mondal et al 2012), antiproliferative (Zhang et al 2014, antifeedant, anti-stress (Budhiraja et al 2000), insecticidal, phytotoxic and antiparasitic (Misico et al 2011).…”

Section: Introductionmentioning

confidence: 85%

Eburneolins A and B, new withanolide glucosides from Tricholepis eburnea

Maher

Rasool

Mehmood

et al. 2016

Natural Product Research

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“…It is known that natural metabolites, including lipids, can contain halogen atoms, such as fluorine, chlorine, bromine and iodine, are introduced into marine organisms (Dembitsky and Tolstikov, 2003;Gribble, 2015;Dembitsky, 2002Dembitsky, , 2006 but in plants, chlorine atoms are predominantly found (Gribble, 2010(Gribble, , 2015Misico et al, 2011;Chen et al, 2011;Dembitsky and Tolstikov, 2003).…”

Section: Chlorinated Plant Steroidsmentioning

confidence: 99%

Chlorinated Plant Steroids and their Biological Activities

Dembitsky¹,

Gloriozova²,

Poroikov³

2017

Int. J. Curr. Res. Biosci. Plant Biol.

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A b s t r a c t A r t i c l e I n f oThe present review describes the biological activities of natural plant chlorinated steroids. About forty biologically active chlorinated steroids have shown confirmed cytostatic, antineoplastic, anti-eczematic, antidiabetic, antibacterial, and other activities. The structures and reported and predicted activities of chlorinated steroids are available. With the computer programme PASS and based on structure-activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review emphasizes the role of chlorinated steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.

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Withanolides and Related Steroids

Cited by 80 publications

References 246 publications

Impacts of methyl jasmonate and phenyl acetic acid on biomass accumulation and antioxidant potential in adventitious roots of Ajuga bracteosa Wall ex Benth., a high valued endangered medicinal plant

Impacts of methyl jasmonate and phenyl acetic acid on biomass accumulation and antioxidant potential in adventitious roots of Ajuga bracteosa Wall ex Benth., a high valued endangered medicinal plant

Eburneolins A and B, new withanolide glucosides from Tricholepis eburnea

Chlorinated Plant Steroids and their Biological Activities

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