Withanolides from Physalin angulata and Their Inhibitory Effects on Nitric Oxide Production

Abstract

Six new withanolides, angulasteroidins AÀ F (1 -6), along with twelve known analogs (7-18) were isolated from the whole plants of Physalis angulata. Their structures were elucidated by analysis of 1D and 2D NMR, ECD and IR spectra, HR-ESI-MS data, and ECD calculation. Compounds 1 and 6 were rare 1 -10 seco withanolides. Compounds 2-4, 7-9, and 15 exhibited significant inhibitory activity on the production of nitric oxide in the LPS-activated RAW 264.7 mouse macrophage cell lines with IC 50 values ranging from 0.23 to 9.06 μM.

Target Separation and Potential Anticancer Activity of Withanolide-Based Glucose Transporter Protein 1 Inhibitors from Physalis angulata var. villosa

“…Mao-Ku-Zhi (MKZ), the whole plant of Physalis angulata L. var. villosa , is a popular folk herb, belonging to the genus Physalis ( Solanaceae ) and is commonly grown in east, central, south, and southwest China . It has also been found in Japan, India, Australia, and North and South America .…”