Withanolides: Phytoconstituents with significant pharmacological activities

Abstract

Withanolides are a group of naturally occurring oxygenated ergostane type steroids, having lactone in side chain and 2-en-1-one system in the ring. Withanolides are present in medicinal plants of Solanaceae family. Formulations based on these medicinal plants are widely used in Ayurveda and traditional Chinese medicine. Withanolides have shown a wide range of pharmacological activities including hypno¬sedative, immunomodulatory, anti-inflammatory, antiarthritic, angiogenesis inhibitor, anticholinesterase, antioxidant, antibacterial and above all, antitumour. Withaferin A is the best studied withanolide as far as pharmacological investigations are concerned. The present review summarises the investigative work carried out on bioactive withanolides.

Assessment of the Consciousness Energy Healing Treated <i>Withania Somnifera</i> (Ashwagandha) Root Extract Using LC-MS, GC-MS, and NMR Spectroscopy

“…The GC-MS ( Figure 4) and NMR data ( Figure 5) also supported the presence of any of these compounds 9-15. These compounds had lots of pharmacological activity and used for various disease [2][3][4][5][6][7][8][9][10]43]. The peak area% was increased significantly by 62.26% in the Biofield Energy Treated sample as compared to the treated sample ( Figure 2e).…”

“…Isolated withanolides possess various pharmacological activities such as antioxidant, anticancer, neuroprotective, immunomodulating, anti-inflammatory, antiarthritic, hepatoprotective, antimicrobial, hypoglycaemic, etc. [10][11][12]. Thus, ashwagandha root extract was considered as one of the components in a novel proprietary herbomineral formulation which can be used as nutraceutical supplement for the prevention and treatment of various disorders.…”

Evaluation of the Energy of Consciousness Healing Treated <i>Withania Somnifera</i> (Ashwagandha) Root Extract Using LC-MS, GC-MS, and NMR Spectroscopy

“…Isolated withanolides from W. somnifera possess various pharmacological activities include antioxidant, anticancer, immunomodulating, neuroprotective, hepatoprotective, anti-inflammatory, antiarthritic, antimicrobial, hypoglycaemic, etc. [10][11][12]. Therefore, ashwagandha root extract was considered as one of the components in a novel proprietary herbomineral formulation and can be used for the prevention and treatment of various human disorders.…”

Chromatographic and Spectroscopic Characterization of the Consciousness Energy Healing Treated <i>Withania somnifera</i> (Ashwagandha) Root Extract

“…Isolated withanolides from ashwagandha possess various pharmacological activities include antioxidant, immunomodulating, neuroprotective, hepatoprotective, antiinflammatory, hypoglycaemic, anticancer, antiarthritic, antimicrobial, etc. [10][11][12]. Thus, ashwagandha root extract was included as one of the constituents in a novel proprietary herbomineral formulation, which can be used for the better quality of life and prevention and treatment of various disorders.…”