Withdrawal of High-Carbohydrate, High-Fat Diet Alters Status of Trace Elements to Ameliorate Metabolic Syndrome in Rats With Type 2 Diabetes Mellitus

Kalita, Himadri; Hazarika, Ankita; Devi, Rajlakshmi

doi:10.1016/j.jcjd.2019.10.001

Cited by 15 publications

(14 citation statements)

References 27 publications

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“…Such an alteration appeared mainly attributed to the impairment of insulin sensitivity, as indicated by the increase in HOMA-IR, HOMA-β and insulinogenic index. These findings are in close agreement with previous studies showing the diabetogenic effect of a high-fructose diet (Kalita et al 2020;Tran et al 2009;Yokozawa et al 2008). However, rats assigned to the P-HF diet displayed an improvement of insulin resistance, glucose tolerance and decreased values for glucose AUC for IPGTT, a significant reduction in glucose, insulin, insulinogenic index, HOMA-β, and fructose levels compared to rats following the C-HF diet, suggesting that dietary proteins source may affect glucose metabolism differentially.…”

Section: Discussionsupporting

confidence: 92%

Pumpkin seed proteins (Cucurbita pepo L.) protect against diet-induced metabolic syndrome by improving insulin resistance and markers of oxidative stress and inflammation in rats

et al. 2022

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Pumpkin (Cucurbita pepo L.) seeds are enriched in bioactive compounds having functional properties. The aim of this study was to analyze the pumpkin seed proteins (PSP) effects on insulin resistance, oxidative stress damage and inflammation in rats with high fructose-induced metabolic syndrome.Twenty four male Wistar rats, fed isoenergetic diets supplemented with: (1) 20% casein (C); (2) 20% casein and 1 g/kg/day PSP (P); (3) 20% casein and 64% D-fructose (C-HF); (4) 20% casein, 1 g/kg/day PSP and 64% D-fructose (P-HF). After 8 weeks of treatment, fructose supply impaired white adipose tissue (WAT) weight, deteriorated glucose tolerance and tAUC, plasma glucose, insulin, insulinogenic index, HOMA-IR and HOMA-β, antioxidant status, lipid and protein oxidation, plasma TNF-α and IL-6 as compared to control diets. Interestingly, rats assigned to the PSPs diet with or without fructose displayed lower plasma glucose, insulin and fructose, improved tolerance of glucose, tAUC, HOMA-IR and HOMA-β and increased insulinogenic index as compared to C diets. PSPs consumption lowered thiobarbituric acid reactive substances, hydroperoxides and carbonyls in WAT and carbonyls in muscle. Superoxide dismutase and glutathione peroxidase in WAT were significantly diminished in P-HF but increased in P as compared to C-HF and C. Rats fed P-HF diet had low catalase in WAT and high in muscle than those fed C-HF. Moreover, catalase activity increased in muscle but decreased in WAT in P group than in C group. In conclusion, pumpkin seed proteins exhibit favorable effects on metabolic disorders of fructose-induced metabolic syndrome, suggesting a key role in disease therapy.

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Section: Discussionsupporting

confidence: 92%

Pumpkin seed proteins (Cucurbita pepo L.) protect against diet-induced metabolic syndrome by improving insulin resistance and markers of oxidative stress and inflammation in rats

et al. 2022

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“…In a previous study from our lab, we found that zinc ions are related to menopause, and supplementation of zinc ions has a positive effect on the treatment of coronary heart disease [26]. Kalita H et al confirmed that changes in the content of trace elements can improve insulin resistance caused by type 2 diabetes [28]. The study demonstrated that magnesium and manganese are cofactors of a variety of related enzymes, and low levels of these elements increase the risk of metabolic syndrome.…”

Section: Introductionmentioning

confidence: 81%

Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis

et al. 2022

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(1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance of trace elements in the body caused by nutritional factors can lead to the progression of coronary atherosclerosis. (2) Methods: We measured the concentrations of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), Zinc (Zn), and iron (Fe) in peripheral blood samples from 4243 patients and performed baseline analysis and propensity matching of the patient datasets. The patients were grouped into acute myocardial infarction (AMI, 702 patients) and stable coronary heart disease (SCAD1, 253 patients) groups. Both of these groups were included in the AS that had a total of 1955 patients. The control group consisted of 2288 patients. The plasma concentrations of calcium, magnesium, and iron were measured using a colorimetric method. For comparison, 15 external quality assessment (EQA) samples were selected from the Clinical Laboratory Center of the Ministry of Health of China. SPSS software was used for statistical analysis. The average values and deviations of all of the indicators in each group were calculated, and a p-value threshold of <0.05 was used to indicate statistical significance. (3) Results: The iron ion concentrations of the acute myocardial infarction (AMI) group were significantly lower than the control group (p < 0.05, AUC = 0.724, AUC = 0.702), irrespective of tendency matching. Compared to the data from the stable coronary artery disease (SCAD) group, the concentration of iron ions in the acute myocardial infarction group was significantly lower (p < 0.05, AUC = 0.710, AUC = 0.682). Furthermore, the iron ion concentrations in the (AMI + SCAD) group were significantly lower (p < 0.05) than in the control group. (4) Conclusions: The data presented in this study strongly indicate that the concentration of iron ions in the peripheral blood is related to coronary atherosclerosis. Decreases in the levels of iron ions in the peripheral blood can be used as a predictive biomarker of coronary atherosclerosis.

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“…In our previous study, we found that Cu level increased in the masseter muscle of rats with MetS while Fe and Mn levels were like those of controls (16). In the literature, increased Fe and Cu levels and decreased Mn and Zn levels were reported in liver of rats fed a high carbohydratehigh fat diet for up to 16 weeks (38). Flores et al…”

Section: Nestorov Et Al Reported An Increased Expression Ofmentioning

confidence: 77%

Alterations in Antioxidant Defence Systems and Metal Profiles in Liver of Rats with Metabolic Syndrome Induced with High-Sucrose Diet

Alptekin

Tukel

Turan

et al. 2022

Journal of the Turkish Chemical Society Section A: Chemistry

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Metabolic syndrome (MetS) is a combination of several different metabolic disorders and considered one of the major public health problems worldwide. The underlying causes of MetS include being overweight and obesity, physical inactivity, and genetic factors. We aimed to examine the alterations in the levels of biomarkers of oxidative stress, activities of antioxidant defense enzymes, and metal contents of the liver in rats with MetS. Rats in control and MetS groups were fed with standard rat chow-drinking water and standard rat chow - 32% sucrose solution (instead of drinking water) ad libitum for 16 weeks, respectively. Following the confirmation of MetS, antioxidant enzyme activities and malondialdehyde (MDA), 3-nitrotyrosine (3-NT), phospho-Akt (pSer473) levels were measured in the homogenates of the liver. Distributions of elements in the liver were also analyzed. The stained hepatic tissue slides were examined by light microscopy. The activities of catalase and glutathione-S-transferase were significantly decreased in MetS-group (about 15% and 29%, respectively) compared to the control group, while the glutathione reductase activity and MDA and 3-NT levels were significantly increased (as the levels of 78%, 26%, and 67%, respectively) (p<0.05). The hepatocytes in the MetS group showed mild diffuse microvesicular steatosis. Furthermore, Cu, Fe, and Mn levels were significantly high in MetS-group while Zn level was significantly low compared to the control group. Our results showed increased oxidative stress, impaired antioxidant defense enzyme activities, and altered metals’ metabolisms which may have an important role in the pathogenesis of MetS.

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Withdrawal of High-Carbohydrate, High-Fat Diet Alters Status of Trace Elements to Ameliorate Metabolic Syndrome in Rats With Type 2 Diabetes Mellitus

Cited by 15 publications

References 27 publications

Pumpkin seed proteins (Cucurbita pepo L.) protect against diet-induced metabolic syndrome by improving insulin resistance and markers of oxidative stress and inflammation in rats

Pumpkin seed proteins (Cucurbita pepo L.) protect against diet-induced metabolic syndrome by improving insulin resistance and markers of oxidative stress and inflammation in rats

Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis

Alterations in Antioxidant Defence Systems and Metal Profiles in Liver of Rats with Metabolic Syndrome Induced with High-Sucrose Diet

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