WITHDRAWN: AMPK α Succinylation modification of protein K266 enhances lipid metabolism and promotes growth of non-small cell lung cancer cells
喜连 汤,
xiao-qin Huang,
Zheng Jian
et al.
Abstract:Objective: The succinylation level of the AMPKα1 protein at K266 is higher in non-small cell lung cancer tissues than normal tissues, but its relationship with NSCLC development is unclear and thus needs to be investigated.
Methods: AMPKα1-knockout and mutant cell lines that simulate AMPKα1 succinylated and desuccinylated at K266 were generated via CRISPR/Cas9 and site-directed mutagenesis technology. The effects of AMPKα1 succinylation at K266 on the proliferation, apoptosis and lipid metabolism of NSCLC cell… Show more
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