2023
DOI: 10.21203/rs.3.rs-2812493/v1
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WITHDRAWN: Analysis of heterogeneity in subpopulations of breast cancer using single-cell RNA sequencing

Abstract: Breast cancer is a complex disease with high levels of intra-tumor heterogeneity. Single-cell RNA sequencing (scRNA-seq) can identify the gene expression profile of different cell subpopulations, revealing key subpopulations that drive tumor progression and therapeutic resistance. We analyzed single-cell RNA-seq data from 26 primary tumors from three major clinical breast cancer subtypes. We inferred copy number variation (CNV) and identified 8 clusters of malignant epithelial cells, with Cluster 1 being the m… Show more

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“…51 Cluster 15 was identified as myoblasts expressing the markers Nrxn1 and Ttn (Figures 2A,B, S2A and Table S3). 52,53 Taken together, we have successfully identified major cell types of the musk gland and identified a series of cell identity specific signature genes, which enable bona fide characterization of cellular heterogeneity.…”
Section: Cell Partitioning Through the Analysis Of The Musk Gland Sin...mentioning
confidence: 99%
“…51 Cluster 15 was identified as myoblasts expressing the markers Nrxn1 and Ttn (Figures 2A,B, S2A and Table S3). 52,53 Taken together, we have successfully identified major cell types of the musk gland and identified a series of cell identity specific signature genes, which enable bona fide characterization of cellular heterogeneity.…”
Section: Cell Partitioning Through the Analysis Of The Musk Gland Sin...mentioning
confidence: 99%