WITHDRAWN: Corrigendum to ”A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse mode” [Biochem. Biophys. Res. Commun. 359 (2007) 419–425]

Choi, Hyeong In; Eo, Haekwan; Park, Kyoungcheol; Jin, Myung; Park, Eun Jin; Kim, Seung‐Chul; Park, Jeong Euy; Kim, Sun‐Young

doi:10.1016/j.bbrc.2007.08.038

Cited by 4 publications

(2 citation statements)

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“…One of the most common characteristics of people with obesity is the development of a fatty liver. 18,19) Hence, we performed a histological analysis to examine the effect of GBR on the development of fatty liver. Large hepatic lipid droplets were present diffusely in the livers of the HFD control group mice (Fig.…”

Section: Liver Histopathologymentioning

confidence: 99%

Anti-Obesity Effects of Germinated Brown Rice Extract through Down-Regulation of Lipogenic Genes in High Fat Diet-Induced Obese Mice

Son

Lim

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Section: Liver Histopathologymentioning

confidence: 99%

Anti-Obesity Effects of Germinated Brown Rice Extract through Down-Regulation of Lipogenic Genes in High Fat Diet-Induced Obese Mice

Son

Lim

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…In recent years, it has been suggested that natural components from food and/or herbal medicines can be recommended as cholesterol-lowering agents. [2][3][4][5][6][7][8] Cholesterol absorption, an effective way of lowering cholesterol levels, provides multiple therapeutic targets in the management of hypercholesterolemia. 9,10 Cholesterol absorption is a complex process that involves multiple pathways.…”

Section: Introductionmentioning

confidence: 99%

Black rice and anthocyanins induce inhibition of cholesterol absorption in vitro

Yao

Zhang

et al. 2013

Food Funct.

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Black rice (Oryza sativa L.) is often associated with blood lipid control. This study systematically assessed the inhibition of cholesterol absorption in vitro by black rice and explored cholesterol-lowering compounds present in this rice. Our results indicated that black rice extracts (BRE), which were aqueous, ethanol extracts and a fraction of macroporous resin caused the reduction of cholesterol absorption by inhibiting pancreatic lipase, decreasing the micellar cholesterol solubility and suppressing cholesterol uptake in Caco-2 cells. The inhibitory activity was positively associated with anthocyanin (cyanidin-3-glucoside (Cy-3-G) and peonidin-3-glucoside (Pn-3-G)) contents of the extracts. Therefore, the cholesterol absorption inhibiting properties of anthocyanins were further explored. The IC50 values of Cy-3-G and Pn-3-G against pancreatic lipase were 42.53 ± 4.45 and 18.13 ± 4.22 μg mL(-1), respectively. Kinetic analysis suggested that the enzymatic inhibitory mode of Cy-3-G and Pn-3-G belonged to the competitive type. In mixed micelles, Cy-3-G and Pn-3-G dose dependently reduced the solubility of cholesterol. Meanwhile, a potential mechanism of cholesterol reduction by anthocyanins was investigated. Results showed that anthocyanins led to precipitation of cholesterol from micellar solution, which may induce the reduction of cholesterol. In Caco-2 cells, Cy-3-G and Pn-3-G (40 μg mL(-1)) exhibited a significant reduction in cholesterol uptake, and the degree of this reduction was almost the same as that observed in the group treated with Ezetimibe at the same concentration. These findings provide important evidence that anthocyanins may partly contribute to the inhibitory effects of black rice on cholesterol absorption, and thus may be applied for the prevention and treatment of hypercholesterolaemia.

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Potential Lipolytic Effect of Panduratin A Loaded Microspicule Serum as a Transdermal Delivery Approach for Subcutaneous Fat Reduction

Jitsaeng,

Duangjit,

Sritananuwat

et al. 2023

Biological & Pharmaceutical Bulletin

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Boesenbergia rotunda (L.) Mansf contained a potent anti-obesity agent. The objectives of this study were to investigate the anti-adipogenesis and lipolysis effects of panduratin A from B. rotunda extract and develop extract-loaded lipolytic body microspicule (MS) serum. Panduratin A that was separated from the ethanolic extract of B. rotunda in fraction 3 (BP-3) were studied the bioactivity of 3T3-L1 preadipocyte cells. The extract-loaded MS serum was formulated and evaluated for safety and efficacy. The BP-3 extract containing panduratin A at 0.29 g per g of the extract was not toxic to the cells at concentrations lower than 10 µg/mL, and the antiadipogenesis and lipolysis effects of the BP-3 extract were strong at 10 µg/mL. To deliver bioactive panduratin A into and through the skin, MS serum was successfully formulated. Application of BP-3 extract-loaded MS serum to the human thigh for 14 d reduced the thigh circumference and increased skin hydration and firmness. Although the skin erythema was increased, no severe redness or pain was found. In conclusion, BP-3 extract acts as a potent bioactive compound to inhibit adipocyte cells, and the antiadipogenesis and lipolysis effects of BP-3 extract in MS serum might play an important role as a potential lipolytic body product for reducing human subcutaneous fat mass.

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WITHDRAWN: Corrigendum to ”A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse mode” [Biochem. Biophys. Res. Commun. 359 (2007) 419–425]

Cited by 4 publications

References 0 publications

Anti-Obesity Effects of Germinated Brown Rice Extract through Down-Regulation of Lipogenic Genes in High Fat Diet-Induced Obese Mice

Anti-Obesity Effects of Germinated Brown Rice Extract through Down-Regulation of Lipogenic Genes in High Fat Diet-Induced Obese Mice

Black rice and anthocyanins induce inhibition of cholesterol absorption in vitro

Potential Lipolytic Effect of Panduratin A Loaded Microspicule Serum as a Transdermal Delivery Approach for Subcutaneous Fat Reduction

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