WITHDRAWN: Deeply understanding delivery of Tetracycline under different morphologies of ZIF-8

Abstract

Facile and biocompatible fabrication of ZIF-8 (zeolite imidazole framework) and its modifications are reported in two ways: TiO2@ZIF-8 and creating mesoporous. Adding a small amount of surfactant changes the traditional crystal morphology to mesoporous and reduces the amount of base needed compared to normal synthesis, thus minimizing environmental impact. The resulting crystals were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Infrared Spectroscopy meter (FTIR), and nitrogen adsorption measurements, which revealed the mesoporous and TiO2@ZIF-8 with polyhedral morphology. The examination of Tetracycline (TC) delivery was thoroughly studied on these hybrids ZIF-8. The loading and release of TC were controlled under the influence of factors such as morphology, and electrostatic force... by experiment data and estimating mechanism. For the first time, the number of molecules of TC adsorbed outer ZIF-8 surface area and inside its structure was investigated. This study demonstrates a green synthesis of mesoporous and TiO2@ZIF-8, maintaining an excellent yield and scalability, successfully applying for TC delivery study, and exposes the important effects of the porous structure on drug loading and release.