WITHDRAWN: Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015

Abstract

Purpose To describe the epidemiology of meningioma operated in France between 2006 and 2015. Methods We processed the French Brain Tumour Database (FBTDB) to conduct a nationwide population-based study of all histopathologically confirmed meningioma in France. Descriptive methods were implemented. Results 30,223 meningiomas cases were operated on 28,424 patients, in 61 centres. Meningioma was 3 times more common in women (74.1% vs. 25.9%). Mean age at surgery was 58.5±13.9 years; 57.9±13.5 years for women vs.59.9 ±14.8 years for men (p<0.001). The incidence of meningioma surgery increased with age. Grade 1, 2, and 3 meningiomas accounted for 83.9%, 13.91% and, 2.19% respectively. The proportion of grade 2 significantly grew over the study period (p<0.001). There was a significant variability of meningioma grading by institutions, especially for grade 2 which spanned from 5.1% up to 22.4% (p <0.001). 89.05% of the patients had solely one meningioma surgery, 8.52% two and, 2.43% three or more. The number of surgeries was associated with the grade of malignancy (p <0.001). Conclusion The FBTBD is an effective source that comforts previous studies and, bring new information from 30,223 meningiomas cases operated on over a 10-year-long period. Three quarters of meningioma were removed in women. The incidence of meningioma surgery increased with age and, peaked at 58.5 years. They were predominantly benign with meningothelial subtype being the most common. However, the rate of grade 2 has significantly grown over the time, on contrary to malignant meningioma proportion, which remained rare and stable over time around 2%.