WITHDRAWN: Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression

Atmosudigdo, Indriwanto Sakidjan; Pranata, Raymond; Lim, Michael Anthonius; Henrina, Joshua; Yonas, Emir; Vania, Rachel; Radi, Basuni

doi:10.1016/j.jceh.2021.01.007

Cited by 21 publications

(16 citation statements)

References 46 publications

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“…Interestingly, all of these had severe disease and/or comorbidities (i.e., diabetes, hypertension or cardiovascular disorders, chronic lung disease and HIV infection, dyslipidemia). These observations are in agreement with previous studies that reported an association between SARS-CoV-2 RNA persistence with severe disease [15,21] and comorbidity [19,[22][23][24] following remission of the acute symptoms. More recently, Jacobs et al highlighted the association between SARS-CoV-2 plasma viremia and ICU admission [25], and Tokuyama et al described SARS-CoV-2 persistence in intestinal enterocytes up to 7 months after symptoms resolutions [26].…”

Section: Discussionsupporting

confidence: 93%

Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19

et al. 2021

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Viral and host immune kinetics during acute COVID-19 and after remission of acute symptoms need better characterization. SARS-CoV-2 RNA, anti-SARS-CoV-2 IgA, IgM, and IgG antibodies, and proinflammatory cytokines were measured in sequential samples from hospitalized COVID-19 patients during acute infection and six months following diagnosis. Twenty four laboratory confirmed COVID-19 patients with mild/moderate and severe COVID-19 were included. Most were males (83%) with a median age of 61 years. Twenty one percent were admitted to the intensive care unit (ICU) and eight of them (33.3%) met the criteria for severe COVID-19 disease. A delay in SARS-CoV-2 levels’ decline during the first six days of follow up, and viral load persistence until month 3 were related to severe COVID-19, but not viral load levels at the diagnosis. Higher levels of anti-SARS-CoV-2 IgA, IgM, IgG and the cytokines IL-6, IL-8 and MIP-1β at the diagnosis time were related to the severe COVID-19 outcome. Higher levels of MIP-1β, IL-1β, MIP-1α and IFN-γ were observed at month 1 and 3 during mild/moderate disease, compared to severe COVID-19. IgG persisted at low levels after six months of diagnosis. In conclusion, higher concentrations of IgA, IgM, and IgG, and IL-6, IL-8 and MIP-1β are identified as early predictors of COVID-19 severity, whereas no significant association is found between baseline SARS-COV-2 viral load and COVID-19 severity.

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Section: Discussionsupporting

confidence: 93%

Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19

et al. 2021

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“…The disease severity was higher in the overweight and obese categories and male gender in current study encompassed a greater percentage in these categories, this finding is also supported by previous studies. 13,14 The three divisions of participants according to age was group 1 with ages between 1 -30 years, group 2 with ages between 31 -60 years and group 3 with ages between 61 -90 years. The major portion totaling 84 participants out of 130 in group 1 were underweight or normal weight, whereas 46 out of 130 were overweight and obese.…”

Section: Resultsmentioning

confidence: 99%

Impact of BMI on Covid-19 Clinical Features and its Management: A Cross Sectional Study

Anwar¹,

Masud²,

Rafique³

et al. 2021

PJMHS

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The whole world is suffering from COVID-19 pandemic. This disease has halted life and has a negative impact on physical and mental health of all individuals. Objectives: To identify impact of BMI on Covid-19 clinical features and its management in terms of relationship among patients at government hospitals, Pakistan. Study Design: Cross-sectional study. Methodology: This study enrolled 206 patients having both genders and was carried at Life Diabetes Centre, Gujrat and CMH Kharian Medical College (CKMC), over a period of 3 months, Kharian-Pakistan following ethical review committee’s (ERC) approval. Statistical analysis: Data was analyzed by SPSS software, version 17. Parameters like age, gender and treatment taken were presented as frequency. Chi square was applied to see the correlation with p-value <0.05 as significant. Results: Total 206 patients were randomly selected, 89 male and 117 females. Among 206, patients (n=133) showed symptoms while rest of the patients (73) remained asymptomatic. There was no association of BMI with COVID-19 symptoms having P-value greater than 0.05. There was an association of BMI with gender as P-value (0.000*). There was an association of BMI with age having P-value (0.000*). Conclusion: From present study, we concluded that there was a correlation between BMI and individuals with higher BMI as they developed more serious symptoms and required active management strategies in comparison to individuals who were either underweight or normal weight. Key Words: Covid-19, BMI, Treatment and Gender.

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“…Of the risk factors for COVID-19 considered in this study, dyslipidemia was the most prevalent, affecting nearly four-fifths of shift workers (77.9%). A meta-analysis by Atmosudigdo et al (2021) 17 evaluating 9 studies with 3663 patients, found that subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR: 1.39; 95% IC = 1.03-1.87; I2: 57.4%, p =.029). And the association was stronger in older patients, male, and hypertensive 17 .…”

Section: Discussionmentioning

confidence: 99%

Work hours as a risk factor for SARS-CoV-2 infections: cardiometabolic and sleep characteristics in rotating shift workers

Nascimento¹,

Fajardo²,

Menezes³

et al. 2022

Sleep Sci

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Objective: This study aims to describe the health characteristics of rotating shift mining workers that may be related to a worse course scenario for COVID-19, according to literature data. Methods: Is a cross-sectional from three studies with 1478 shift workers. Social, demographic, clinical, and biochemical variables were analyzed. Risk factors for COVID-19 analyzed: hyperglycemia, altered blood pressure, dyslipidemia, hypovitaminosis D, obesity, presence of pre-existing cardiovascular diseases, and smokers. Results: Evaluating the grouped risk factors for an unfavorable evolution of COVID-19 most workers (91.0%) presented at least one risk factor. Discussion: With coronavirus in pandemic circulation, we noticed that mineworkers are in a vulnerable position. Their exposure to occupational risk factors, to the shift system, which directly affects sleep and negatively influences immunity, added to the conditions of favorable transmissibility by the flow of people from the mines leads us to believe in their greater susceptibility to acquiring the most serious forms of the disease.

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WITHDRAWN: Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression

Cited by 21 publications

References 46 publications

Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19

Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19

Impact of BMI on Covid-19 Clinical Features and its Management: A Cross Sectional Study

Work hours as a risk factor for SARS-CoV-2 infections: cardiometabolic and sleep characteristics in rotating shift workers

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