WITHDRAWN: Genetic complexity alters drug susceptibility of asexual and gametocyte stages ofP. falciparumto antimalarial candidates
Nicola Greyling,
Mariëtte van der Watt,
Hazel Gwarinda
et al.
Abstract:Malaria elimination requires interventions able to target both the asexual blood stage (ABS) parasites and transmissible gametocyte stages of Plasmodium falciparum. Lead antimalarial candidates are evaluated against clinical isolates to address key concerns regarding efficacy and confirm that the current, circulating parasites from endemic regions lacks resistance against these candidates. Whilst this has largely been performed on ABS parasites, limited data is available on the transmission-blocking efficacy o… Show more
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