WITHDRAWN: In-silico discovery of novel microtubule inhibitors targeting colchicine binding site; A combined Group-based QSAR approach

Abstract

Microtubules are a potential target for the design and development of novel anti-mitotic drugs for cancer therapy Focusing on their mechanisms of action, Microtubuletargeting agents are classified into stabilizers and destabilizers, among them destabilizers binding to colchicine binding site domain is an important source of research in recent years. A number of molecules containing indole scaffold have been described as tubulin polymerization inhibitors with the potential to interact with the colchicine binding site. The research is focused on the search for new indole-based colchicine binding site inhibitors, for that fragment-based QSAR utilized for the important interacting site for potent fragment attachment and the designed fragment library screened for the finding of the potent molecule and finally, three molecules screened and validated for their reactivity using DFT and stability using Molecular dynamics simulation, among them m16 showing the potential result with high interaction energy, high molecular reactivity and confirms high stability as compared to others.