WITHDRAWN: Involvement of KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: A systematic review

Santos, Marcos; Abreu, Anna Karolina de Carvalho; Silva, Fábio Willian Martins da; Ferreira, Elaine Barros; Reis, Paula Elaine Diniz dos; Rabello, Doralina do Amaral

doi:10.1016/j.oor.2023.100058

Search citation statements

Order By: Relevance

Paper Sections

Select...

Protocol and Registration1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database under the number CRD42020197780. 20…”

Section: Protocol and Registrationmentioning

confidence: 99%

KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: A systematic review

da Silva Santos,

de Carvalho Abreu,

Martins da Silva

et al. 2023

Head & Neck

View full text Add to dashboard Cite

BackgroundThe involvement of the KMT2 methyltransferase family in the pathogenesis of head and neck squamous cell carcinoma (HNSCC) remains elusive.MethodThis study adhered to the PRISMA guidelines, employing a search strategy in the LIVIVO, PubMed, Scopus, Embase, Web of Science, and Google Scholar databases. The methodological quality of the studies was assessed by the Joanna Briggs Institute.ResultsA total of 33 studies involving 4294 individuals with HNSCC were included in this review. The most important alteration was the high mutational frequency in the KMT2C and KMT2D genes, with reported co‐occurrence. The expression of the KMT2D gene exhibited considerable heterogeneity across the studies, while limited data was available for the remaining genes.ConclusionsKMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation.

show abstract

“…19 The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database under the number CRD42020197780. 20…”

Section: Protocol and Registrationmentioning

confidence: 99%