WITHDRAWN: LncRNA EGOT regulates the proliferation and apoptosis of colorectal cancer by miR-33b-5p/CROT axis

Yin, Ning; Li, Chunbo; Chen, Bo; Zhang, Bomiao; Liu, Yanlong; Bai, Xuefeng; Cui, Bingbing; Han, Peng

doi:10.1042/bsr20193893

Cited by 12 publications

(9 citation statements)

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“…Of note, Chen et al (2018) reported that IKZF1 overexpression promoted immune infiltration in several tumor types, and enhanced the efficacy of anti-PD1 and anti-CTLA4 treatment. Besides, non-coding RNAs in our study, including LINC00324 (Ni et al, 2019;Zhang M. et al, 2020), miR-9-5p (Ma et al, 2020;Wang et al, 2020), and miR-33b-5p (Huang G. et al, 2020;Ni et al, 2020), were also reported in literatures to be associated with the prognosis of various cancer types.…”

Section: Discussionsupporting

confidence: 73%

Identification of a ceRNA Network in Lung Adenocarcinoma Based on Integration Analysis of Tumor-Associated Macrophage Signature Genes

Zhang

et al. 2021

Front. Cell Dev. Biol.

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As research into tumor-immune interactions progresses, immunotherapy is becoming the most promising treatment against cancers. The tumor microenvironment (TME) plays the key role influencing the efficacy of anti-tumor immunotherapy, in which tumor-associated macrophages (TAMs) are the most important component. Although evidences have emerged revealing that competing endogenous RNAs (ceRNAs) were involved in infiltration, differentiation and function of immune cells by regulating interactions among different varieties of RNAs, limited comprehensive investigation focused on the regulatory mechanism between ceRNA networks and TAMs. In this study, we aimed to utilize bioinformatic approaches to explore how TAMs potentially influence the prognosis and immunotherapy of lung adenocarcinoma (LUAD) patients. Firstly, according to TAM signature genes, we constructed a TAM prognostic risk model by the least absolute shrinkage and selection operator (LASSO) cox regression in LUAD patients. Then, differential gene expression was analyzed between high- and low-risk patients. Weighted gene correlation network analysis (WGCNA) was utilized to identify relevant gene modules correlated with clinical characteristics and prognostic risk score. Moreover, ceRNA networks were built up based on predicting regulatory pairs in differentially expressed genes. Ultimately, by synthesizing information of protein-protein interactions (PPI) analysis and survival analysis, we have successfully identified a core regulatory axis: LINC00324/miR-9-5p (miR-33b-5p)/GAB3 (IKZF1) which may play a pivotal role in regulating TAM risk and prognosis in LUAD patients. The present study contributes to a better understanding of TAMs associated immunosuppression in the TME and provides novel targets and regulatory pathway for anti-tumor immunotherapy.

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Section: Discussionsupporting

confidence: 73%

Identification of a ceRNA Network in Lung Adenocarcinoma Based on Integration Analysis of Tumor-Associated Macrophage Signature Genes

Zhang

et al. 2021

Front. Cell Dev. Biol.

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“…Based on our bioinformatics prediction, and verified by dual-luciferase assay, we revealed that TP53TG1 serves as a competing endogenous (ceRNA) in its negative regulation of miR-33b in RB. MiR-33, specifically miR-33a and miR-33b, belongs to a family of highly conserved miRNA 34 , that are known tumor suppressors for cancers like HER2 positive breast carcinoma 35 , colorectal cancer 36 , and lung cancer 37 . Being a potential tumor suppressor, breast HER2 + tumor samples showed a marked downregulation of miR-33b, as opposed to normal breast tissues.…”

Section: Discussionmentioning

confidence: 99%

Long Non-Coding RNA TP53TG1 Upregulates SHCBP1 to Promote Retinoblastoma Progression by Sponging miR-33b

Wang

Zhang

et al. 2021

Cell Transplant

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Long non-coding RNA (lncRNA) TP53 target 1 (TP53TG1) is known to be strongly associated with tumor and cancer progression. However, its expression profile, unique role, and regulatory pathways in retinoblastoma (RB) are not known. Here, we revealed a large expression of TP53TG1 in RB tissues and cell lines. Conversely, we showed marked suppression of cell proliferation, migration, and invasion in TP53TG1 knocked down RB cells. Mechanistically, we established that TP53TG1 directly interacted with microRNA (miR)-33b in RB cells. Furthermore, TP53TG1 transcripts were found to be inversely correlated with miR-33b in RB tissues. We also showed that miR-33b suppression partly reversed the TP53TG1 knockdown mediated effects on tumor biology. Finally, TP53TG1 was shown to modulate the levels of SHC Binding and Spindle Associated 1 (SHCBP1), a direct target of miR-33b in RB cells. Based on the above data, we propose that TP53TG1 regulates RB progression via its modulation of the miR-33b/SHCBP1 pathway.

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“… 28 Furthermore, it is found that EGOT can promote the apoptosis of CC through microRNA-33b-5p/CROT axis. 29 However, the predictive value of EGOT in clinical diagnosis of CC is still unclear. In this research, we first analyzed the expression of EGOT in CC.…”

Section: Discussionmentioning

confidence: 99%

“…Compared with the study of Ni et al, 29 this study was designed to analyze the diagnostic value of LncRNA EGOT in CC, and the ceRNA map was mapped by miR and its downstream mRNA which could bind to LncRNA EGOT . In addition, we also carried out a nude mouse experiment to verify the inhibitory effect of LncRNA EGOT on tumor growth in vivo.…”

Section: Discussionmentioning

confidence: 99%

Study on Clinical Significance of LncRNA EGOT Expression in Colon Cancer and Its Effect on Autophagy of Colon Cancer Cells

Liu¹,

Zhang²,

Cao³

et al. 2020

CMAR

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WITHDRAWN: LncRNA EGOT regulates the proliferation and apoptosis of colorectal cancer by miR-33b-5p/CROT axis

Cited by 12 publications

References 0 publications

Identification of a ceRNA Network in Lung Adenocarcinoma Based on Integration Analysis of Tumor-Associated Macrophage Signature Genes

Identification of a ceRNA Network in Lung Adenocarcinoma Based on Integration Analysis of Tumor-Associated Macrophage Signature Genes

Long Non-Coding RNA TP53TG1 Upregulates SHCBP1 to Promote Retinoblastoma Progression by Sponging miR-33b

Study on Clinical Significance of LncRNA EGOT Expression in Colon Cancer and Its Effect on Autophagy of Colon Cancer Cells

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