WITHDRAWN: Neuroprotective action of Gmelina arborea (bark) and Punica granatum (peel) extracts

Pai, Vasudev; Shreedhara, CS; Chandrashekar, K. S.; Yamini, D

doi:10.1016/j.ajps.2015.11.004

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…Pomegranate extracts have also shown a dose-dependent neuroprotective potential against the MPTP-Induced cytotoxicity and oxidative stress in human primary neurons (Braidy et al, 2013). When the aqueous extract of the pomegranate(peel) was evaluated for the neuroprotective potential, it has shown antioxidant assay (DPPH assay) having IC50 values of 32.89µg, 28.25µg and acetylcholinesterase inhibition analysis with IC50 values of 387.5µg and 201.3µg Vasudev et al (2015). It was investigated that the consumption of pomegranate peel extract helps to protect or prevent the progression and establishment of the neurodegenerative process through the reduction of amyloid plaque density, acetylcholinesterase enzyme, and lipid peroxidation when induced in mice by infusion with amyloidβ peptide (Morzelle et al, 2016).…”

Section: Effects Of Punica Granatum As Neuroprotective Agentmentioning

confidence: 99%

Pharmacognostical And Pharmacological Activity of Punica Granatum (Pomegranate): An Overview

Anjali¹,

Ashish²,

K³

et al. 2020

ijrps

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Punica granatum (PG) Linn (Family Punicaceae) is also known as pomegranate in English and commonly known as Anar in Hindi, it is found in the nearby region of Iran and very often found in the Himalayas and northern region of India and also cultivated since the ancient times, all over the region of Africa, Europe, and Asia. The various parts of pomegranate plants like seeds, leaf, root, and rind, in the traditional medicine system, used to treat multiple disease ailments such as wound healing, antioxidant, anti-inflammatory, decreases cancer risks, anti-arthritic, anti-proliferative and many more diseases.Punica granatum Linn. f. has an excellent level of pharmacological action, which very important according to the medicinal point of view. An enormous variety of phytochemicals such as alkaloids, flavonoids, saponin, carbohydrates, steroids, triterpenoids, carotenoids, amino acids, tannins, phenolics, and coumarins. This plant (PG) is very rich in phenolic compounds, due to the presence of such a wide variety of phytoconstituents. The whole plant was extensively used during the holistic medicine system in the treatment of the number of disease treatment.This review mainly focused on the large variety of essential pharmacognostic and pharmacological profile that is necessary to exhibit the crucial therapeutic activity and phytopharmacological properties of different parts of Punica granatum.

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Section: Effects Of Punica Granatum As Neuroprotective Agentmentioning

confidence: 99%

Pharmacognostical And Pharmacological Activity of Punica Granatum (Pomegranate): An Overview

Anjali¹,

Ashish²,

K³

et al. 2020

ijrps

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“…The plant Gmelina arborea reported to have various pharmacological activities, especially nootropics, epilepsy, and other CNS disorders [16]. Gmelina asiatica and Gmelina arabica belong to the same genus and have similar phytochemical pro les [17]. The following phytoconstituents were reported from these plants, i.e., cycloolivil, spathulenol, nicoti orin, gmelinol, quercetagetin, pinoresinol, sakuranetin, luteolin-7-glucuronide, poulownin and isorhoifolin which we considered for the current study (Fig.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective upshot of isorhoifolin flavonoid of Gmelina asiatica for multitargeted approach in Alzheimer's disease: Exploration through in-silico studies

Andarghiske,

Kancharla,

Siva

2023

Preprint

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Alzheimer's is a progressive neurodegenerative disease with amyloid-beta peptide deposition that impairs memory and cognitive decline. In previous reports, the plant Gmelina asiatica was reported to have anti-Alzheimer’s disease (AD) activity. However, the responsible chemical constituents of G. asiatica for anti-Alzheimer’s activity have not been explored. Therefore, the present study aimed to investigate hit compounds through an in silico approach. The reported phytoconstituents were initially screened through auto dock software. Then, the lead compound was further evaluated through molecular dynamic studies. Further hit compound isorhoifolin physicochemical and ADMET properties were analyzed. In docking studies, isorhoifolin showed the least binding energy and well resided at the active sites of AchE (-10.9 kcal/mol), BACE1 (-10.2 kcal/mol), GSK-3 (-9.7 kcal/mol), TACE1 (-9 kcal/mol). Further molecular dynamic simulation revealed that isorhoifolin is stable up to 200 ns. Furthermore, density functional theory (DFT) was analyzed using Gaussian software, where the quantum mechanics objective was focused. Besides, the physicochemical properties of isorhoifolin were studied, such as absorption, distribution, metabolism, excretion, and toxicity, through the pkcsm software. The study suggests isorhoifolin from the Gmelina asiatica plant may be responsible for anti-Alzheimer's activity, which may be considered for further investigation.

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Pomegranate Bioactive Molecules and Health Benefits

Akhtar¹,

Ismail²,

Layla³

2018

Reference Series in Phytochemistry

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WITHDRAWN: Neuroprotective action of Gmelina arborea (bark) and Punica granatum (peel) extracts

Cited by 5 publications

References 3 publications

Pharmacognostical And Pharmacological Activity of Punica Granatum (Pomegranate): An Overview

Pharmacognostical And Pharmacological Activity of Punica Granatum (Pomegranate): An Overview

Neuroprotective upshot of isorhoifolin flavonoid of Gmelina asiatica for multitargeted approach in Alzheimer's disease: Exploration through in-silico studies

Pomegranate Bioactive Molecules and Health Benefits

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