WITHDRAWN: Utilizing comparative models in biomedical research

Little, Alexander G.; Pamenter, Matthew E.; Sitaraman, Divya; Templeman, Nicole M.; Willmore, William G.; Hedrick, Michael S.; Moyes, Christopher D.

doi:10.1016/j.cbpa.2021.110938

Cited by 2 publications

(1 citation statement)

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“…These changes in the liver and serum of overfed geese are similar to those in humans with NAFLD. Therefore, waterfowl is the model animal in biomedical research for non-alcoholic fatty liver ( 10 ). Some research studies have been carried out to reveal the mechanism of goose fatty liver formation.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Wei,

Teng,

Han

et al. 2024

Front. Vet. Sci.

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To comprehensively provide insight into goose fatty liver formation, we performed an integrative analysis of the liver transcriptome, lipidome, and amino acid metabolome, as well as peripheral adipose tissue transcriptome analysis using samples collected from the overfed geese and normally fed geese. Transcriptome analysis showed that liver metabolism pathways were mainly enriched in glucolipid metabolism, amino acid metabolism, inflammation response, and cell cycle; peripheral adipose tissue and the liver cooperatively regulated liver lipid accumulation during overfeeding. Liver lipidome patterns obviously changed after overfeeding, and 157 different lipids were yielded. In the liver amino acid metabolome, the level of Lys increased after overfeeding. In summary, this is the first study describing goose fatty liver formation from an integrative analysis of transcriptome, lipidome, and amino acid metabolome, which will provide a whole new dimension to understanding the mechanism of goose fatty liver formation.

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Section: Introductionmentioning

confidence: 99%

Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Wei,

Teng,

Han

et al. 2024

Front. Vet. Sci.

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Neural Processing without O₂ and Glucose Delivery: Lessons from the Pond to the Clinic

Amaral-Silva,

Santin

2024

Physiology

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Neuronal activity requires a large amount of ATP, leading to a rapid collapse of brain function when aerobic respiration fails. Here, we summarize how rhythmic motor circuits in the brainstem of adult frogs, which normally have high metabolic demands, transform to produce proper output during severe hypoxia associated with emergence from hibernation. We suggest that general principles underlying plasticity in brain bioenergetics may be uncovered by studying non-mammalian models that face extreme environments, yielding new insights to combat neurological disorders involving dysfunctional energy metabolism.

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WITHDRAWN: Utilizing comparative models in biomedical research

Cited by 2 publications

References 158 publications

Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Neural Processing without O₂ and Glucose Delivery: Lessons from the Pond to the Clinic

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WITHDRAWN: Utilizing comparative models in biomedical research

Cited by 2 publications

References 158 publications

Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Neural Processing without O2 and Glucose Delivery: Lessons from the Pond to the Clinic

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Neural Processing without O₂ and Glucose Delivery: Lessons from the Pond to the Clinic