2021
DOI: 10.1101/2021.03.20.436248
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Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

Abstract: The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because most studies have focused on within-host virus diversity of infections in otherwise healthy adults based on single timepoint data. Here, we analysed the within-host evolution of 82 longitudinally sampled individuals, mostly young children, infected with A/H3N2 or A/H1N1pdm09 viruses between 2007 and 2009. For A/H… Show more

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Cited by 2 publications
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“…We found the fewest iSNVs in the H1N1 group ( n = 9 ferrets), with an average of 24 iSNVs per ferret, ranging from 3 to 35 across all time points. This is similar to the number of seasonal influenza virus iSNVs reported in humans ( Han et al. 2021 ).…”
Section: Resultssupporting
confidence: 88%
“…We found the fewest iSNVs in the H1N1 group ( n = 9 ferrets), with an average of 24 iSNVs per ferret, ranging from 3 to 35 across all time points. This is similar to the number of seasonal influenza virus iSNVs reported in humans ( Han et al. 2021 ).…”
Section: Resultssupporting
confidence: 88%
“…We found the fewest iSNVs per ferret in the CA04 group (n=9 ferrets), with an average of 24 iSNVs per ferret, ranging from 3-83. This is similar to the number of seasonal flu iSNVs reported in humans 35 . The number of iSNVs in the rGD/3 group (n=13 ferrets, grouping both rGD/3 viruses) was also low, with an average of 13 per ferret, ranging from 1-43.…”
Section: Resultssupporting
confidence: 88%