2021
DOI: 10.1016/j.aej.2020.12.011
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Within-host mathematical modeling on crucial inflammatory mediators and drug interventions in COVID-19 identifies combination therapy to be most effective and optimal

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Cited by 28 publications
(47 citation statements)
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“…The simulation is done using matlab software and ode solver ode45 is used to solve the system of equations. The parameter values of the within-host sub-model used in simulation is taken from [9]. These within-host parameter values are used in calculating the area under the viral load curve N h .…”
Section: Numerical Illustrations Of the Stability Of Equilibrium Pointsmentioning
confidence: 99%
See 1 more Smart Citation
“…The simulation is done using matlab software and ode solver ode45 is used to solve the system of equations. The parameter values of the within-host sub-model used in simulation is taken from [9]. These within-host parameter values are used in calculating the area under the viral load curve N h .…”
Section: Numerical Illustrations Of the Stability Of Equilibrium Pointsmentioning
confidence: 99%
“…Some of the important mathematical modelling studies that deal with transmission and spread of COVID-19 at between-host level can be found in [7,23,25,39,32,28,40,24,38,10,41,4,33]. Within-host mathematical modelling studies that deal with the interplay between the viral dynamics and immune response of COVID-19 disease can be found in [8,36].…”
Section: Introductionmentioning
confidence: 99%
“…Most of these studies ignore the intercellular delay by assuming that the infectious process is instantaneous, which may not be biologically true [21]. A detailed study of the SIV model developed on the basis of pathogenesis dealing with COVID -19 is carried out by the authors in [9]. In the present work, a model is developed and studied that takes into account the intercellular time delay.…”
Section: Model Without Interventionsmentioning
confidence: 99%
“…In the article [10], the authors have done an extensive study on the role of antiviral drugs such as Arbidol, Remdesivir, Lopinavir and Ritonavir and immunomodulators such as INF, and Zinc in COVID-19 infection. In this work initially, we extend the work done in [9] by incorporating inter-cellular time delay and do the stability analysis of the equilibrium points admitted by the model. Secondly, an optimal control problem is framed with antiviral agents and second-line drugs as control measures incorporating the adverse events caused by antiviral drugs and their roles in reducing the infected cell count and the viral load is studied.…”
Section: Introductionmentioning
confidence: 99%
“…Cehhetri et al. [12] developed a mathematical within-host model and found that the combination of therapies including antiviral and immunomodulating drugs were optimal and most effective. Also, within-host models can help us to differentiate groups of patients with high mortality, Néant et al.…”
Section: Introductionmentioning
confidence: 99%