Within-session changes in sensory gating assessed by p50 evoked potentials in normal subjects

Test–retest reliability of P50, N100 and P200 auditory sensory gating in healthy subjects

“…In contrast, reliability for the classical N40-P50 ratio-gating, i.e. P50 component referenced to N40 component, was inadequate; this was in line with previous results (Boutros et al, 1991a,b;Clementz et al, 1998a;Hall et al, 2006;Kathmann and Engel, 1990;Lamberti et al, 1993;Naber et al, 1992;Smith et al, 1994). Surprisingly however, most clinical studies still use N40-P50 ratio-gating instead of P50 ratio-gating; e.g.…”

“…In healthy subjects, reports of within-session retest stability and between-session retest stability of up to two weeks have ranged from 0 to 0.3 (Boutros et al, 1991a,b;Clementz et al, 1997;Kathmann and Engel, 1990;Naber et al, 1992;Smith et al, 1994). Better test-retest correlations (0.47 and 0.66) were reported by Lamberti et al (1993) and in a more recent study by Hall et al (2006). However, in a re-examination of Lamberti's data by Smith et al (1994) the correlations ranged from 0.1 to 0.5.…”

Effects of Diazepam on Auditory Evoked Potentials of Rats Elicited in a Ten-Tone Paradigm

“…Decreased amplitudes, or sensory gating, of middle-latency AEP components with stimulus repetition are in agreement with results from studies employing the 2-tone paradigm in both humans [31,32] and rats [26,33].…”

P50 amplitude reduction: a nicotinic receptor-mediated deficit in first-degree relatives of schizophrenia patients

“…Further characterization of the genetic and neurophysiological underpinnings of P50 amplitude, as an endophenotype distinct from P50 gating, is, therefore, warranted. Given its sensitivity to pharmacological manipulation and its robust test-retest reliability (Boutros et al 1991;Lamberti et al 1993;Fuerst et al 2007), it may be especially useful as a potential index of efficacy of novel pharmaceutical agents targeting cognitive and information-processing deficits in schizophrenia.…”