Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis
Aidan Evans‐Strong,
Najah Walton,
Katrina Blandino
et al.
Abstract:Neurosteroids have been implicated in the pathophysiology of post‐traumatic stress disorder (PTSD). Allopregnanolone is reduced in subsets of individuals with PTSD and has been explored as a novel treatment strategy. Both direct trauma exposure and witnessed trauma are risk factors for PTSD; however, the role of neurosteroids in the behavioral outcomes of these unique experiences has not been explored. Here, we investigate whether observational fear is associated with a reduced capacity for endogenous neuroste… Show more
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