Wivern: a Web-Based System Enabling Computer-Aided Diagnosis and Interdisciplinary Expert Collaboration for Vascular Research

Novo, Jorge; Rouco, José; Barreira, N.; Penedo, Manuel G.; Campilho, Aurélio

doi:10.1007/s40846-017-0256-y

Cited by 12 publications

(4 citation statements)

References 45 publications

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“…Over the recent years, the constant technological advances allow the integration of specialized computed-aided diagnosis systems in different fields of medicine [20,21,23]. These systems ease the doctor's work, facilitating and accelerating the diagnosis and monitoring of many diseases, in addition to the inclusion of important advantages as objectivity and determinism that are not always present in the diagnostic processes of the experts in their clinical routine.…”

Section: Introductionmentioning

confidence: 99%

Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images

et al. 2019

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Angiography by Optical Coherence Tomography (OCT-A) is a non-invasive retinal imaging modality of recent appearance that allows the visualization of the vascular structure at predefined depths based on the detection of the blood movement through the retinal vasculature. In this way, OCT-A images constitute a suitable scenario to analyze the retinal vascular properties of regions of interest as is the case of the macular area, measuring the characteristics of the foveal vascular and avascular zones. Extracted parameters of this region can be used as prognostic factors that determine if the patient suffers from certain pathologies (such as diabetic retinopathy or retinal vein occlusion, among others), indicating the associated pathological degree. The manual extraction of these biomedical parameters is a long, tedious and subjective process, introducing a significant intra and inter-expert variability, which penalizes the utility of the measurements. In addition, the absence of tools that automatically facilitate these calculations encourages the creation of computer-aided diagnosis frameworks that ease the doctor’s work, increasing their productivity and making viable the use of this type of vascular biomarkers. In this work we propose a fully automatic system that identifies and precisely segments the region of the foveal avascular zone (FAZ) using a novel ophthalmological image modality as is OCT-A. The system combines different image processing techniques to firstly identify the region where the FAZ is contained and, secondly, proceed with the extraction of its precise contour. The system was validated using a representative set of 213 healthy and diabetic OCT-A images, providing accurate results with the best correlation with the manual measurements of two experts clinician of 0.93 as well as a Jaccard’s index of 0.82 of the best experimental case in the experiments with healthy OCT-A images. The method also provided satisfactory results in diabetic OCT-A images, with a best correlation coefficient with the manual labeling of an expert clinician of 0.93 and a Jaccard’s index of 0.83. This tool provides an accurate FAZ measurement with the desired objectivity and reproducibility, being very useful for the analysis of relevant vascular diseases through the study of the retinal micro-circulation.

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Section: Introductionmentioning

confidence: 99%

Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images

et al. 2019

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“…The main cause of stenosis and occlusion of the internal carotid artery or vertebral artery is atherosclerosis. Cervical spondylosis bone hyperplasia or skull base into the compression of the vertebral artery can also cause vertebral artery ischemia [23]. The study found that the incidence of stroke in Chinese population is higher than that of heart disease, contrary to the European and American population.…”

Section: A Stroke Cause and Treatment Processmentioning

confidence: 89%

Design and Implementation of Networked Collaborative Service System for Brain Stroke Prevention and First Aid

Manogaran²

2019

IEEE Access

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Brain stroke is one of the three most deadly diseases in humans, especially since the time window from onset to treatment is very short, and this time determines whether the patient can get effective treatment. In addition, although individuals store a large amount of historical medical information in various medical organizations, the information is isolated and does not play its value. In response to the above-mentioned problems, the business needs of the Brain stroke prevention and emergency services have analyzed, and a networked collaborative service system for brain stroke prevention and first aid has been designed and implemented. The services of the brain stroke prevention and first aid networked collaborative service system discover and select candidate services, design service interfaces, and promote the collaborative work of medical organizations. Because the system involves the patient's medical data, it has related to personal privacy. In the following work, this paper needs to further improve the security aspects of the system to ensure the safety and reliability of the patient health information data.INDEX TERMS Brain stroke, medical information, emergency service, networked collaborative service, first aid.

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“…Каждое исследование предоставляет автоматический анализ с ретинографией, ультразвуком сонных артерий и контролем артериального давления, а также обеспечивает автоматический расчет для оценки сердечно-сосудистых рисков. Приложение Wivern позволяет проводить междисциплинарное и комплексное исследование сосудистой сети [17].…”

Section: современные подходы к изучению сосудов глазного дна при гипеunclassified

Modern Aspects of Hypertensive Angioretinopathy

Lk¹,

Воробьева²,

Dgebuadze³

2019

Oftalʹmologiâ

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This literature review is devoted to modern problems of hypertensive retinopathy with arterial hypertension, as well as hypertensive retinopathy in combination diseases. The latest world studies were analyzed. Particular attention is paid to the clinical disease characteristics at the present stage with the analysis of the arterio-venous ratio, optic nerve edema (with high blood pressure figures) using an automated system, vector analysis, suggesting a new arteriovenous classification, called Web Integration (Wivern). The modern pathogenesis of hypertensive retinopathy, namely the ratio of proangiogenic and anti-angiogenic factors, the role of inflammation (C-reactive protein), the role of endothelin-1, endostatin, interleukin-8 (IL-8), and the main fibroblast growth factor (bFGF ), angiogenin and uric acid. The special importance of fundus registration is reflected with the help of the newest equipment at high figures of arterial pressure in patients with hypertensive retinopathy. It is known that according to the World Health Organization (WHO), mortality rate from cardiovascular diseases is 31 %. Hypertension is the main risk factor for coronary heart disease, myocardial infarction, heart failure, stroke, kidney disease and early death. Questions of eye blood flow in hypertensive angioretinopathy in patients with arterial hypertension (AH) are covered. Hypertensive retinopathy (HR) is a retinal disease that is caused by a prolonged increase blood pressure (BP) and leads to a decrease in vision. The data of pathophysiology are analyzed (arterial hypertension (AH) leads to thickening of the vessels of the inner membrane (intima), to thickening of the medial membrane (media) — hyperplasia of the muscular tissue followed by hyaline degeneration with the development of sclerotic changes). The questions of modern diagnostics with retinal morphological status evaluation (OCT), detection of eye fundus condition with newest fundus camers, pathogenetic aspects are discussed. This review will help to prevent the development of more severe forms of hypertensive retinopathy. This information will allow us to identify the most significant indicators in the early diagnosis of hypertension angioretinopathy.

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Wivern: a Web-Based System Enabling Computer-Aided Diagnosis and Interdisciplinary Expert Collaboration for Vascular Research

Cited by 12 publications

References 45 publications

Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images

Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images

Design and Implementation of Networked Collaborative Service System for Brain Stroke Prevention and First Aid

Modern Aspects of Hypertensive Angioretinopathy

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