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Abstract

Embelin was one of active constituents of Embelia ribes Burm. f. Embelin has been reported to possess many pharmacological effects. The studies as was perform to enhance the bioavailability of poorly water soluble embelin, reduce the dose of Embelin, prevent the degradation of Embelin in the GIT. For this, phytosome, a novel drug delivery system, was adopted. Total six Embelin loaded phytosome complex formulations coded as EMBP1, EMBP2, EMBP3, EMBP4, EMBP5 and EMBP6 using soya lecithin and Chitosan in variable ratio were prepared by anti-solvent precipitation method and Rotary evaporation technique. The phytosome was characterized by parameters like percentage yield, particle size determination, entrapment efficiency, scanning electron microscopy (SEM), in-vitro release studies and establish drug release kinetic studies. Among six formulations, the Formulation EMBP5 well optimized. EMBP5 exhibits lowest 345.45 ±1.231 diameter. The entrapment efficiency of Embelin loaded phytosome complex varies from 64.99 ± 1.546 to 81.78 ± 1.151%. Embelin loaded phytosome complex formulation (EMBP5) exhibits highest of 81.78 ± 1.151% entrapment efficiency. SEM photomicrographs of optimized formulation (EMBP5) of Embelin loaded phytosome complex showed that the phytosomes are less spherical with smooth and rough surface and slightly aggregated. In-vitro dissolution study of phytosomes showed extended release pattern. From the data, the release of embelin from Embelin loaded phytosome complex was by fickian diffusion mechanism and followed first order kinetics (concentration dependant). INTRODUCTION:According to WHO, more than 80% people of the world shows their reliability towards herbal medicines. Active constituents extracted from plants have been used to treat various diseases since ancient times 1 . Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. However, the drug delivery system used for QUICK RESPONSE CODE