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Abstract

The study carried out to find the effect of Aloe vera extract on the toxicity induced by INH -RIF in male Wistar albino rats. We have perform the experiments on rats for 30 days and found the effect on histological alternations of liver by two different method. Firstly, by Compound microscopy and the same tissues were further process through SEM microscopy. We have found the effect of Aloe vera extract and isoniazid and rifampicin on histological architecture of liver. We found that there is partial restoration of hepatic function as evident from normalization of serum markers of liver function, and we were able to show hepatoprotection against INH+RIF induced hepatotoxicity, as evidenced by the partial reversal of increased serum transaminases showed trend towards returning to normal (but partially) by supplementation of Aloe vera indicating partial hepatoprotective effect. Co-administration of Aloe vera extract along with anti-tuberculosis drugs showed hepatoprotection in some extent against INH-RIF drugs.

Curcumin has Curative Effect on Isoniazid-Rifampicin Induced Hepatotoxicity

“…Hepatitis caused by isoniazid and rifampicin is linked to the death of cells in certain regions of the liver as well as centrilobular degeneration 21 . The study found isoniazid and rifampicin had been observed to produce hepatotoxicity in rabbit liver cells, and microscopic examination of these cells indicates inflammation and cell death at focal and centrilobular regions 22,23 .…”