WNK1 et WNK4, nouveaux acteurs de l’homéostasie hydrosodée

Hadchouel, Juliette; Delaloy, Céline; Jeunemaı̂tre, Xavier

doi:10.1051/medsci/200521155

Cited by 10 publications

(3 citation statements)

References 21 publications

(43 reference statements)

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“…In fact, by inhibiting WNK4 activity through kinase phosphorylation, WNK1 controls Na + and Clions transport. Moreover, WNK1 plays a switch role-like (activation/inhibition) of the Na-K-Cl cotransporters (NKCC) respectively [43]. ENPEP is a member of the M1 family of endopeptidases.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the role of salt-sensitivity genes in obesity with integrated network biology and co-expression analysis

et al. 2020

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Obesity is a multifactorial disease caused by complex interactions between genes and dietary factors. Salt-rich diet is related to the development and progression of several chronic diseases including obesity. However, the molecular basis of how salt sensitivity genes (SSG) contribute to adiposity in obesity patients remains unexplored. In this study, we used the microarray expression data of visceral adipose tissue samples and constructed a complex protein-interaction network of salt sensitivity genes and their co-expressed genes to trace the molecular pathways connected to obesity. The Salt Sensitivity Protein Interaction Network (SS PIN) of 2691 differentially expressed genes and their 15474 interactions has shown that adipose tissues are enriched with the expression of 23 SSGs, 16 hubs and 84 bottlenecks (p = 2.52 x 10-16) involved in diverse molecular pathways connected to adiposity. Fifteen of these 23 SSGs along with 8 other SSGs showed a co-expression with enriched obesity-related genes (r � 0.8). These SSGs and their co-expression partners are involved in diverse metabolic pathways including adipogenesis, adipocytokine signaling pathway, renin-angiotensin system, etc. This study concludes that SSGs could act as molecular signatures for tracing the basis of adipogenesis among obese patients. Integrated network centered methods may accelerate the identification of new molecular targets from the complex obesity genomics data.

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Section: Discussionmentioning

confidence: 99%

Unraveling the role of salt-sensitivity genes in obesity with integrated network biology and co-expression analysis

et al. 2020

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“…Le nom étrange de ces kinases est dû au remplacement de la lysine catalytique, pré-sente dans le sous-domaine II de la majorité des protéine kinases connues, par une cystéine [6]. De nombreuses équipes ont étudié la régulation de NCC par les kinases WNK1 et WNK4 [34] ( §). Cependant, les résultats obtenus étaient souvent contradictoires et un modèle clair et unique expliquant le mécanisme de régulation de l'expression et de l'activité du cotransporteur NCC par les WNK n'a jamais pu être établi.…”

Section: Wnk1-wnk4 Et Hypertension Hyperkaliémique Familialeunclassified

Réabsorption du sel et sécrétion du potassium par le néphron distal

2016

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“…L'hypervolémie secondaire entraîne une diminution de la sécrétion de rénine. De plus, le canal potassique ROMK, site majeur de sécrétion du potassium, est inhibé, ce qui provoque une hyperkaliémie qui stimule la production d'aldostérone (mais de manière insuffisante d'où une hypoaldostéronémie relative) [8]. L'acidose métabolique est une acidose tubulaire de type IV, secondaire à une perturbation de l'excrétion rénale de potassium.…”

Section: Physiopathologieunclassified