Wnt Signaling in Skeletal Muscle Development and Regeneration

Girardi, Francesco; Grand, Fabien Le

doi:10.1016/bs.pmbts.2017.11.026

Cited by 133 publications

(85 citation statements)

References 85 publications

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“…The later phases of regeneration are characterized by the expression of Wnt3a and Wnt7b [26,61]. In adult skeletal muscle, canonical Wnt signaling-mainly through the ligand Wnt3a-drives differentiation of satellite cells, while non-canonical Wnt signaling through the ligand Wnt7a is responsible for promoting symmetric satellite cell divisions, migration of satellite cells, and growth of myofibers [26,38,39,56,[62][63][64][65] (Fig. 3).…”

Section: Wnt Signaling During Regeneration Of Skeletal Musclementioning

confidence: 99%

“…This makes Wnt7a a promising candidate for ameliorative treatment of muscle wasting diseases such as muscular dystrophy [66]. A recent publication describes the importance of R-spondin, a known modulator of canonical Wnt signaling for proper differentiation of myogenic progenitor cells during regeneration, further emphasizing the importance of proper Wnt signaling for regeneration of skeletal muscle [64,67,68]. The importance of balanced canonical Wnt signaling for regeneration of skeletal muscle is further highlighted by a recent study from Rudolf et al, who demonstrated that disruption or activation of β-catenin in adult satellite cells impairs the regeneration process [69].…”

Section: Wnt Signaling During Regeneration Of Skeletal Musclementioning

confidence: 99%

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Adult stem cells at work: regenerating skeletal muscle

Schmidt

Schüler

Hüttner

et al. 2019

Cell. Mol. Life Sci.

231

212

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Skeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration. Their functionality is critically modulated by intrinsic signaling pathways as well as by interactions with the stem cell niche. Here, we discuss the properties of satellite cells, including heterogeneity regarding gene expression and/or their phenotypic traits and the contribution of satellite cells to skeletal muscle regeneration. We also summarize the process of regeneration with a specific emphasis on signaling pathways, cytoskeletal rearrangements, the importance of miRNAs, and the contribution of non-satellite cells such as immune cells, fibro-adipogenic progenitor cells, and PW1-positive/Pax7-negative interstitial cells.

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Section: Wnt Signaling During Regeneration Of Skeletal Musclementioning

confidence: 99%

Section: Wnt Signaling During Regeneration Of Skeletal Musclementioning

confidence: 99%

Adult stem cells at work: regenerating skeletal muscle

Schmidt

Schüler

Hüttner

et al. 2019

Cell. Mol. Life Sci.

231

212

View full text Add to dashboard Cite

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“…during the various stages of skeletal muscle repair and regeneration, correct activation of the Wnt signaling pathways is crucial. Wnt1 and Wnt4 mainly activate the canonical Wnt pathway (37). However, Wnt7a did not activate β-catenin in myoblasts or muscle myofibers.…”

Section: Discussionmentioning

confidence: 90%

“…The Wnt signaling pathway is weakly activated in mature skeletal muscle. However, after injury, satellite cells are activated in the skeletal muscle, where numerous Wnt ligands (such as Wnt1, Wnt3a, Wnt4 and Wnt7a/b) are expressed and secreted (37). Moreover, Leroux et al (48) reported that MScs, via the Wnt4 pathway, improved skeletal muscle fiber regeneration following ischemic injury.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, c2c12 cells were used in the present study. Wnt/β-catenin signaling plays an important role in satellite cell self-renewal, myoblast proliferation, fusion and myofiber homeostasis in skeletal muscle (37). Skeletal muscle injury initiates Wnt signaling, thereby activating satellite cells, promoting cell proliferation and differentiation and repairing damaged muscle fibers.…”

Section: Introductionmentioning

confidence: 99%

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The secretome of human dental pulp stem cells protects myoblasts from hypoxia‑induced injury via the Wnt/β‑catenin pathway

Zhang

Han

et al. 2020

Int J Mol Med

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Human dental pulp stem cells (hdPScs) present several advantages, including their ability to be non-invasively harvested without ethical concern. The secretome of hdPScs can promote the functional recovery of various tissue injuries. However, the protective effects on hypoxia-induced skeletal muscle injury remain to be explored. The present study demonstrated that c2c12 myoblast coculture with hdPScs attenuated cocl 2-induced hypoxic injury compared with c2c12 alone. The hdPSc secretome increased cell viability and differentiation and decreased G2/M cell cycle arrest under hypoxic conditions. These results were further verified using hDPSC-conditioned medium (hDPSC-CM). The present data revealed that the protective effects of hdPSc-cM depend on the concentration ratio of the cM. In terms of the underlying molecular mechanism, hdPSc-cM activated the Wnt/β-catenin pathway, which increased the protein levels of Wnt1, phosphorylated-glycogen synthase kinase-3β and β-catenin and the mRNA levels of Wnt target genes. By contrast, an inhibitor (XAV939) of Wnt/β-catenin diminished the protective effects of hdPSc-cM. Taken together, the findings of the present study demonstrated that the hDPSC secretome alleviated the hypoxia-induced myoblast injury potentially through regulating the Wnt/β-catenin pathway. These findings may provide new insight into a therapeutic alternative using the hdPSc secretome in skeletal muscle hypoxia-related diseases.

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circHIPK3 regulates proliferation and differentiation of myoblast through the miR‐7/TCF12 pathway

Gao

Yang

et al. 2021

Journal Cellular Physiology

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Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR‐7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.

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Wnt Signaling in Skeletal Muscle Development and Regeneration

Cited by 133 publications

References 85 publications

Adult stem cells at work: regenerating skeletal muscle

Adult stem cells at work: regenerating skeletal muscle

The secretome of human dental pulp stem cells protects myoblasts from hypoxia‑induced injury via the Wnt/β‑catenin pathway

circHIPK3 regulates proliferation and differentiation of myoblast through the miR‐7/TCF12 pathway

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