2001
DOI: 10.1002/1521-4141(200101)31:1<285::aid-immu285>3.0.co;2-d
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Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

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Cited by 175 publications
(51 citation statements)
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“…Wnt-1 and Wnt-4 signals were not involved in the differentiation of thymocytes from the fetal liver-derived precursors in the thymus. Taken together with the role of TCF-1 signaling thymocytes [9][10][11][12] the data presented here suggests that Wnt-1 and Wnt-4 provide proliferative and/or survival signals to developing thymocytes through TCF-1-mediated gene expression.…”
Section: Resultssupporting
confidence: 53%
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“…Wnt-1 and Wnt-4 signals were not involved in the differentiation of thymocytes from the fetal liver-derived precursors in the thymus. Taken together with the role of TCF-1 signaling thymocytes [9][10][11][12] the data presented here suggests that Wnt-1 and Wnt-4 provide proliferative and/or survival signals to developing thymocytes through TCF-1-mediated gene expression.…”
Section: Resultssupporting
confidence: 53%
“…Wnt-1, Wnt-4 and Wnt-3A were expressed in DN thymocytes with similar frequency as seen in total thymocytes (data not shown). Expression of Wnt-1 and Wnt-4 in the thymus was independently reported while this work was in progress [12].…”
Section: Resultsmentioning
confidence: 84%
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“…In contrast, targeting of the Tcf-1 gene in mice leads to stage-specific blockage in thymocyte development and a reduction in thymus size, but mice appear otherwise normal (Staal et al, 2001).…”
Section: Tcf-1 and Lef-1mentioning
confidence: 94%