Wnt/β-catenin pathway in bone cancers

Tian, Jing; He, Hongbo; Lei, Guanghua

doi:10.1007/s13277-014-2433-8

Cited by 78 publications

(50 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have indicated that the Wnt signaling pathway serves an important role in cell proliferation, differentiation, survival and apoptosis, and is implicated in various tumor types (20,21). In the present study, it was observed that hsa-miR-185-5p was significantly dysregulated in chordoma tissues and had the potential to target the Wnt signaling pathway.…”

Section: Discussionsupporting

confidence: 52%

MicroRNA profiling and bioinformatics analyses reveal the potential roles of microRNAs in chordoma

Chen

Zhang

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

Abstract. Chordoma is a rare aggressive bone tumor arising from remnants of the notochord, and patients with chordoma have a poor prognosis. However, the unique expression profiles of microRNAs (miRNAs/miRs) and their downstream signaling pathways in chordoma remain incompletely characterized. The aim of the present study was to delineate the global miRNA expression profile and associated signaling networks in chordoma. miRNA profiling was performed on chordoma and fetal notochord tissues. Differentially expressed miRNAs in chordoma were analyzed using microarrays with hierarchical clustering analysis. The target genes of the differentially expressed miRNAs were predicted, and Gene Ontology (GO) and pathway analyses were performed for the intersecting genes. A total of 42 miRNAs were significantly dysregulated in chordoma compared with that in fetal nucleus pulposus tissues. The expression of hsa-miR-21-3p, hsa-miR-150-5p, hsa-miR-1290 and hsa-miR-623 were validated using the reverse transcription-quantitative polymerase chain reaction. On the basis of the intersection predicted by three databases (Targetscan, microRNA.org and PITA), 10,292 potential miRNA targets were identified. Bioinformatic analyses suggested that these dysregulated miRNAs and their predicted targets were functions of signaling pathways in cancer, the mitogen-activated protein kinase signaling pathway, regulation of actin cytoskeleton, focal adhesion and endocytosis. In particular, human (hsa-)miR-185-5p was identified as a crucial miRNA in chordoma development via the Wnt signaling pathway. The results of the present study provide a comprehensive expression and functional profile of differentially expressed miRNAs associated with chordoma. This profile may serve as a potential tool for biomarker and therapeutic target identification in patients with chordoma.

show abstract

Section: Discussionsupporting

confidence: 52%

MicroRNA profiling and bioinformatics analyses reveal the potential roles of microRNAs in chordoma

Chen

Zhang

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…About twenty years ago, causal mutations in the LRP5 gene were identified to be involved in two rare bone disorders, which were related to the Wnt/β-catenin pathway (54)(55)(56). A number of reports were exploded to highlight the role of the Wnt/β-catenin pathway in the regulation of bone homeostasis (57)(58)(59). Recently, the most highlighted members of the LDLR family involved in the maintenance of bone metabolism were LRP5, LRP6, LRP4, and Apoer2 (26,60).…”

Section: Discussionmentioning

confidence: 99%

Multifarious effects of 17-β-estradiol on apolipoprotein E receptors gene expression during osteoblast differentiation <i>in vitro </i>

Gui

Duan

Tang

et al. 2016

BST

View full text Add to dashboard Cite

“…TC-1 protein functions as a positive regulator of the Wnt/β-catenin signaling pathway that regulates cell migration, polarity, and fate determination during embryogenesis. Mutations or epigenetic inactivation of elements of this pathway can lead to birth defects or cancer [38]. TC-1 is thought to competitively block interactions between β-catenin and a repressor protein, leading to upregulation of β-catenin target genes [39].…”

Section: Discussionmentioning

confidence: 99%

Gene expression and pathway analysis of human hepatocellular carcinoma cells treated with cadmium

Cartularo

Laulicht

Sun

et al. 2015

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Cadmium (Cd) is a toxic and carcinogenic metal naturally occurring in the earth’s crust. A common route of human exposure is via diet and cadmium accumulates in the liver. The effects of Cd exposure on gene expression in human hepatocellular carcinoma (HepG2) cells were examined in this study. HepG2 cells were acutely-treated with 0.1, 0.5, or 1.0 μM Cd for 24 hours; or chronically-treated with 0.01, 0.05, or 0.1 μM Cd for three weeks and gene expression analysis was performed using Affymetrix GeneChip® Human Gene 1.0 ST Arrays. Acute and chronic exposures significantly altered the expression of 333 and 181 genes, respectively. The genes most upregulated by acute exposure included several metallothioneins. Downregulated genes included the monooxygenase CYP3A7, involved in drug and lipid metabolism. In contrast, CYP3A7 was upregulated by chronic Cd exposure, as was DNAJB9, an anti-apoptotic J protein. Genes downregulated following chronic exposure included the transcriptional regulator early growth response protein 1. Ingenuity Pathway Analysis revealed that the top networks altered by acute exposure were lipid metabolism, small molecule biosynthesis, and cell morphology, organization, and development; while top networks altered by chronic exposure were organ morphology, cell cycle, cell signaling, and renal and urological diseases/cancer. Many of the dysregulated genes play important roles in cellular growth, proliferation, and apoptosis, and may be involved in carcinogenesis. In addition to gene expression changes, HepG2 cells treated with cadmium for 24 hours indicated a reduction in global levels of histone methylation and acetylation that persisted 72 hours post-treatment.

show abstract

Wnt/β-catenin pathway in bone cancers

Cited by 78 publications

References 54 publications

MicroRNA profiling and bioinformatics analyses reveal the potential roles of microRNAs in chordoma

MicroRNA profiling and bioinformatics analyses reveal the potential roles of microRNAs in chordoma

Multifarious effects of 17-β-estradiol on apolipoprotein E receptors gene expression during osteoblast differentiation <i>in vitro </i>

Gene expression and pathway analysis of human hepatocellular carcinoma cells treated with cadmium

Contact Info

Product

Resources

About