2024
DOI: 10.1016/j.gendis.2023.02.050
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WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

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Cited by 23 publications
(10 citation statements)
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“…The Wnt/β-catenin signaling pathway drives cancer metastasis and therapy resistance [45]. By blocking the Wnt/β-catenin pathway, low expression of TRIM44 in human thyroid cancer cells inhibits cancer cell invasion [46].…”
Section: The Role Of the Tripartite Motif Family In Cancer Signaling ...mentioning
confidence: 99%
“…The Wnt/β-catenin signaling pathway drives cancer metastasis and therapy resistance [45]. By blocking the Wnt/β-catenin pathway, low expression of TRIM44 in human thyroid cancer cells inhibits cancer cell invasion [46].…”
Section: The Role Of the Tripartite Motif Family In Cancer Signaling ...mentioning
confidence: 99%
“…In hepatic cells, Wnt/β-catenin is activated under physiological conditions and is essential for hepatobiliary development and regeneration processes [ 339 ]. It is one of the most dysregulated pathways in HCC, with mutations detected in 62.5% of HCC samples [ 283 ].…”
Section: Review Of Established and Novel Potential Targets In Hccmentioning
confidence: 99%
“…6A-B). We examined several pathways and molecular that in uence cell metastasis, including canonical WNT/β-catenin signaling 19 , RhoA/ROCK1 signaling 20 , RAC1 pathway 21 and EMT inducing transcription factors 22 . Interestingly, only SNAI1 protein levels were signi cantly decreased in TRIM47 silenced cells (Fig.…”
Section: Trim47 Promotes Hcc Metastasis By Protecting Snai1 From Prot...mentioning
confidence: 99%