Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt/β-Catenin signaling pathway in Rex rabbits

Wu, Zhenyu; Zhu, Yanli; Liu, Hongli; Liu, Gongyan; Li, Fuchang

doi:10.1042/bsr20191248

Cited by 33 publications

(38 citation statements)

References 26 publications

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“…Our study falls into this category. Similar to our study, Wu et al [17] found that Wnt10b promotes DPCs' proliferation in Rex rabbits. In contrast, Yu et al [59] demonstrated that mitotic arrest-deficient protein 2B (MAD2B) plays a negative role in T cell factor 4 (TCF4)-induced DPCs' proliferation in humans.…”

Section: Discussionsupporting

confidence: 92%

“…In the process of HF transformation from telogen to anagen, DPCs migrate upward and then reach the bulge. In the bulge, DPCs release signals to activate multiple signaling pathways, especially the Wnt/β-catenin signaling pathway [17], stimulate the differentiation of HFSCs, and promote HF regeneration [18]. In cashmere goat, dermal papilla cells of secondary hair follicle (SHF-DPCs) are the controlling centers of SHF growth.…”

Section: Introductionmentioning

confidence: 99%

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Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat

Dai¹,

Fei²,

Xu³

et al. 2020

IJMS

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Increasing cashmere yield is one of the important goals of cashmere goat breeding. To achieve this goal, we screened the key genes that can improve cashmere performance. In this study, we used the RNA raw datasets of the skin and dermal papilla cells of secondary hair follicle (SHF-DPCs) samples of hair follicle (HF) anagen and telogen of Albas cashmere goats and identified a set of significant differentially expressed genes (DEGs). To explore potential associations between gene sets and SHF growth features and to identify candidate genes, we detected functional enrichment and constructed protein-protein interaction (PPI) networks. Through comprehensive analysis, we selected Thymosin β4 (Tβ4), Rho GTPase activating protein 6 (ARHGAP6), ADAM metallopeptidase with thrombospondin type 1 motif 15, (ADAMTS15), Chordin (CHRD), and SPARC (Osteonectin), cwcv and kazal-like domains proteoglycan 1 (SPOCK1) as candidate genes. Gene set enrichment analysis (GSEA) for these genes revealed Tβ4 and ARHGAP6 have a close association with the growth and development of SHF-DPCs. However, the expression of Tβ4 in the anagen was higher than that in the telogen, so we finally chose Tβ4 as the ultimate research object. Overexpressing Tβ4 promoted and silencing Tβ4 inhibited the proliferation of SHF-DPCs. These findings suggest that Tβ4 can promote the growth and development of SHF-DPCs and indicate that this molecule may be a valuable target for increasing cashmere production.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat

Dai¹,

Fei²,

Xu³

et al. 2020

IJMS

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“…The latest studies carried out on in vitro hair follicle cultures isolated from Rex rabbits showed that Wnt10b promotes hair follicle growth and proliferation of dermal papilla cells (DPCs) through the activation of the Wnt/β‐Catenin signaling pathway (Wu et al . 2020).…”

Section: Molecular Control Of Hair Coat Development In Rabbitsmentioning

confidence: 99%

Rabbits – their domestication and molecular genetics of hair coat development and quality

Dorożyńska

Maj

2020

Animal Genetics

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SummaryThe European rabbit (Oryctolagus cuniculus) is the only representative of its genus living in present‐day Europe and North Africa, and all domestic rabbits are descendants of this one species, which is native to the Iberian Peninsula. There are over 300 breeds of rabbits that differ in size, coat color, length of ears and type of fur. Rabbits are bred for various reasons, such as for laboratory animals and a source of meat, wool and fur, as well as for pets and exhibition animals. The hair coat is a important economic trait of rabbits. Its development and quality are influenced by various factors, both environmental and genetic. The genetic mechanisms underlying its development have not been thoroughly researched. The aim of this review is to discuss the domestication of rabbits and the different aspects of rabbit genetics. A brief review of the properties of rabbit hair coat, hair coat development and hair cycle will be provided, followed by discussion of the factors regulating hair coat development, molecular control of hair coat development and the role of non‐coding RNAs in the regulation of gene expression in the hair follicles of rabbits. Information about genetic regulation of pathways could provide useful tools for improving hair coat quality and be of practical use in rabbit breeding.

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“…Second, the proliferation of DPCs is promoted by the overexpression or inhibition of endogenous genes. Wu et al 17 found that Wnt10b promotes DPC proliferation in Rex rabbits. In contrast, Yu et al 18 demonstrated that mitotic arrest‐deficient protein 2B plays negative roles in T‐cell factor 4–induced DPC proliferation in human beings.…”

Section: Introductionmentioning

confidence: 99%

Multiple potential roles of thymosin β4 in the growth and development of hair follicles

Dai

Ri-na

Yuan

et al. 2021

J Cellular Molecular Medi

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The hair follicle (HF) is an important mini‐organ of the skin, composed of many types of cells. Dermal papilla cells are important signalling components that guide the proliferation, upward migration and differentiation of HF stem cell progenitor cells to form other types of HF cells. Thymosin β4 (Tβ4), a major actin‐sequestering protein, is involved in various cellular responses and has recently been shown to play key roles in HF growth and development. Endogenous Tβ4 can activate the mouse HF cycle transition and affect HF growth and development by promoting the migration and differentiation of HF stem cells and their progeny. In addition, exogenous Tβ4 increases the rate of hair growth in mice and promotes cashmere production by increasing the number of secondary HFs (hair follicles) in cashmere goats. However, the molecular mechanisms through which Tβ4 promotes HF growth and development have rarely been reported. Herein, we review the functions and mechanisms of Tβ4 in HF growth and development and describe the endogenous and exogenous actions of Tβ4 in HFs to provide insights into the roles of Tβ4 in HF growth and development.

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Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt/β-Catenin signaling pathway in Rex rabbits

Cited by 33 publications

References 26 publications

Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat

Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat

Rabbits – their domestication and molecular genetics of hair coat development and quality

Multiple potential roles of thymosin β4 in the growth and development of hair follicles

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