Wnt3a expression is associated with poor prognosis of esophageal squamous cell carcinoma

Ozawa, Soji; Kazuno, Akihito; Nitta, Miho; Ninomiya, Yamato; Kajiwara, Hiroshi

doi:10.3892/ol.2017.7666

Cited by 11 publications

(14 citation statements)

References 37 publications

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“…As previously reported, the aberrant expression of Wnt3a was also found in several human malignancies, including glioblastoma [16,17], mammary adenocarcinoma [18,19], colon carcinoma [20], lung cancer [21], prostate cancer [22], malignant mesothelioma [23], esophageal squamous cell carcinoma [24], hepatocellular carcinoma [25][26][27], and melanoma [28]. In these malignant tumors, Wnt3a expression is closely related to tumor growth, metastasis, chemo-/ radio-resistance and maintenance of CSC characteristics.…”

Section: Discussionsupporting

confidence: 64%

Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma

Zhang

Chen

et al. 2019

J. Cancer

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As a classical ligand in the canonical Wnt/β-catenin signaling pathway, the role of Wnt3a in laryngeal squamous cell carcinoma (LSCC) remains unclear. Therefore, the expression pattern of the Wnt3a protein in 222 primary LSCC, and 19 corresponding adjacent non-carcinoma specimens, was detected by immunohistochemistry and further correlated with clinicopathological parameters. The results showed that LSCC tissue expressed higher levels of the Wnt3a protein when compared to the corresponding adjacent non-cancerous tissues. High expression of Wnt3a was closely related to histological grade (P = 0.031), clinical stage (I+II / III+IV; P = 0.004), and lymph node metastasis (P = 0.03). Kaplan-Meier analysis evidenced that a worse overall survival (OS) was correlated to the group with high Wnt3a expression (P = 0.003). When stratified survival analyses were performed, patients with lymph node metastasis/advanced clinical stages and high Wnt3a expression had worse OS rates than patients with other features (P < 0.001). Finally, multivariate analysis showed that Wnt3a expression was an independent prognosis factor for LSCC patients. The current findings suggest that Wnt3a is tightly related to the LSCC progression and could serve as a valuable clinic biomarker for LSCC patients.

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Section: Discussionsupporting

confidence: 64%

Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma

Zhang

Chen

et al. 2019

J. Cancer

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“…This characteristic history is of great signi cance for the diagnosis of BS [3]. In addition, images including plain chest roentgenograms, oesophagograms, and CT scans also contribute to diagnosing BS [8]. Previous studies have shown that the oesophagogram is a feasible and effective examination for diagnosing oesophageal perforation [5]; however, due to the high false-negative rate of the oesophagogram (15-25%) and tenuous nature of oesophageal rupture, chest CT is considered a more appropriate modality [5,7].…”

Section: Discussionmentioning

confidence: 99%

“…Data from the literature indicate that the golden period for primary repair is the rst 24 hours of the event for oesophageal perforation when it can be associated with a 90% success rate [4]. The principles of treatment include removing the source of pollution, closing the breach, restoring the integrity of the oesophagus, full drainage, controlling the infection, strengthening nutritional support, improving the body and promoting wound healing [3,8]. The traditional management of BS has been prompt surgery [8].…”

Section: Discussionmentioning

confidence: 99%

“…The principles of treatment include removing the source of pollution, closing the breach, restoring the integrity of the oesophagus, full drainage, controlling the infection, strengthening nutritional support, improving the body and promoting wound healing [3,8]. The traditional management of BS has been prompt surgery [8]. Recently, new primary repair methods with interventional endoscopy have been performed widely.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous Oesophageal Rupture of The Right Wall After Oral Administration of Sulfate Solution: An Unusual Case Report

Huang

et al. 2020

Preprint

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Background: Patients with gastrointestinal stenosis, Barrett's oesophagus, and vomiting during endoscopic preconditioning or after general anaesthesia may develop spontaneous oesophageal rupture in the literature. However, we found an unusual case in which oral sulfate solution triggered oesophageal perforation. Additionally, the oesophageal chasm uncommonly presented at the right wall, while most ruptures are located in the left wall of the oesophagus, and the unexplained and rapidly progressive right-sided pleural effusion in this patient could be associated with this entity. To the best of our knowledge, this is the first published case of oesophageal rupture of the right wall after oral administration of sulfate solution in the literature.Case presentation: For this patient, he suffered from acute onset of unbearable epigastric pain and compression pain in the right chest, with dyspnea, chest tightness and palpitation, after severe nausea and vomiting following oral administration of sulfate solution, and findings from imaging and gastroscopy eventually confirmed oesophageal rupture. Anti-infective treatments, pleural drainage, rehydration and total parenteral nutrition were administered immediately; subsequently, we used a total of seven titanium clips to close the oesophageal rupture under gastroscopic guidance. Eventually, he demonstrated good evolution after the operation and was discharged after recovery. Conclusions: This case emphasizes the importance of considering BS when dealing with patients with severe vomiting, acute chest pain, or dyspnea, especially after administration of sulfate solution for bowel cleansing.

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“…The Wnt ligands, of which there are more than 19 closely related but distinct secreted cysteine‐rich glycoproteins, have been characterized according to their roles in early development and tumourigenesis . Wnt3a, a canonical Wnt ligand, is elevated in hepatocellular carcinoma, prostate cancer, oesophageal squamous cell carcinoma, lung adenocarcinoma and colon or colorectal carcinoma . Moreover, increased Wnt3a protein levels are tightly associated with multiple aggressive cancer phenotypes, such as metastasis, advanced clinical stages and worse patient survival status, revealing that Wnt3a is a valuable prognostic biomarker in human malignancy.…”

Section: Discussionmentioning

confidence: 99%

Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

Jing

Chen

et al. 2019

J Cellular Molecular Medi

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The canonical Wnt/β‐catenin signalling pathway and autophagy play critical roles in cancer progression. However, the role of Wnt‐mediated autophagy in cancer radioresistance remains unclear. In this study, we found that irradiation activated the Wnt/β‐catenin and autophagic signalling pathways in squamous cell carcinoma of the head and neck (SCCHN). Wnt3a is a classical ligand that activated the Wnt/β‐catenin signalling pathway, induced autophagy and decreased the sensitivity of SCCHN to irradiation both in vitro and in vivo. Further mechanistic analysis revealed that Wnt3a promoted SCCHN radioresistance via protective autophagy. Finally, expression of the Wnt3a protein was elevated in both SCCHN tissues and patients' serum. Patients showing high expression of Wnt3a displayed a worse prognosis. Taken together, our study indicates that both the canonical Wnt and autophagic signalling pathways are valuable targets for sensitizing SCCHN to irradiation.

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Wnt3a expression is associated with poor prognosis of esophageal squamous cell carcinoma

Cited by 11 publications

References 37 publications

Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma

Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma

Spontaneous Oesophageal Rupture of The Right Wall After Oral Administration of Sulfate Solution: An Unusual Case Report

Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

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