Wnt5a/Platelet‐rich plasma synergistically inhibits IL‐1β‐induced inflammatory activity through NF‐κB signaling pathway and prevents cartilage damage and promotes meniscus regeneration

Qi, Yiying; Tang, Ruofu; Shi, Zuobing; Feng, Gang; Zhang, Wenkan

doi:10.1002/term.3198

Cited by 22 publications

(13 citation statements)

References 45 publications

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“…In general, IL1β is strongly expressed in the joint cartilage, synovium, and meniscus in people with KOA [39].In the first group of the study, it was observed that the level of interleukin-1β decreased significantly after injecting the knee joint with platelet-rich plasma treatment ,It is in agreement with the results Yiying Qi et al, [40] . impacts as seen Chen et al, [41] Previous research has shown mixed results on the involvement of Pure-PRP in cartilage cell regeneration, as well as beneficial.…”

Section: Interleukin-1βsupporting

confidence: 84%

Evaluation of the effect of injectionsof both platelet-rich plasma and hyaluronic acid in patients with early knee osteoarthritis via the concentration of interleukin-1β in serum

Alzamily¹,

Albdeery²

2022

JBB

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BackgroundEarly knee osteoarthritis, which causes the degeneration of articular cartilage and subchondral bone, is a disease that worsens with time and is a major contributor to physical disability. Several inflammatory cytokines released by chondrocytes work in concert to trigger the production of enzymes that break down cartilage. A pro-inflammatory cytokine called interleukin-1β (IL-1 β ) accelerates cartilage breakdown after trauma, reduces matrix production, and results in chondrocyte death. Dendritic cells and macrophages are the main sources of IL-1β. On the other hand, osteoblasts, periodontal ligament cells, and gingival fibroblasts have the ability to release IL-1β. Treatment pure-platelet rich plasma (P-PRP) effectiveness of transforming growth factor, platelet-derived growth factor, type I insulin-like growth factor, and the vascular endothelial growth factor is thought to be related to their release. Because of their capacity to increase matrix formation, growth factors have been widely researched for OA and cartilage regeneration. Hyaluronic acid (HA) is a glycosaminoglycan polymer composed of N-acetyl glucosamine and D-glucuronic acid disaccharide molecules. Early embryonic development, inflammatory, wound repair, cell differentiation, and viscoelasticity are all affected by HA, and other biological processes. Materials and MethodsElabscience kits were used to assess the serum IL-1β level. The experimental investigation included 18 control groups, 10 HA injections, and 21 pure PRP injections. age ranged from 30 to 80. The study was excluded all individuals with advanced osteoarthritis in the knee, COVID-19, diabetes, and autoimmune diseases. the time frame running from November 2021 until June 2022. Other variables in our research were age, gender, family history, use of antihypertensive medications or medications for other disorders, and body mass index (BMI). ResultsThe findings of this study demonstrate elevated IL-1β levels in patients with early KOA before treatments injection compared with the healthy control. After treatments injection, the level of IL-1β was decreased compared with before injection.Conclusions IL-1β could be one of the prognostic signs of early KOA

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Section: Interleukin-1βsupporting

confidence: 84%

Evaluation of the effect of injectionsof both platelet-rich plasma and hyaluronic acid in patients with early knee osteoarthritis via the concentration of interleukin-1β in serum

Alzamily¹,

Albdeery²

2022

JBB

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“…With the fast development of a social process of people making, selling, and buying things and the gradual moving ahead or up of growth of cities with more people, the number of times something happens of breaks caused by violent injuries such as falls from heights and car crashes is increasing, and knee cartilage sports injuries are more common [ 1 ]. As a more common type of joint injury in the clinic, physical labor and excessive exercise are the main factors causing knee injury [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Feedforward Control Combined with 4F Management on Postoperative Nursing Effects and Motor Function of Meniscus Sports Injuries: Based on a Prospective Case Analysis

Lü

2022

Computational and Mathematical Methods in Medicine

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Background. Because active functional training and management after knee cartilage sports injury is the key to treatment, care of patients after an operation with knee cartilage sports injury is critical. Aims. To explore the effect of feedforward control combined with 4F management and after an operation nursing effect on patients with knee cartilage sports injury. Materials and Methods. According to the random number table method, 100 patients with knee cartilage sports injury who were nursed in our hospital from June 2019 to June 2021 were selected as the research objects and divided into the control group and the instance of watching, noticing, or making a statement group with 50 cases in each group according to the different nursing order. Among them, the control group adopted 4F management combined with feedforward control nursing mode: all-weather, whole-process, whole-system, and all-around services for patients. On this basis, the instance of watching, noticing, or making a statement group cooperated with early healing/repairing training to compare fear and stress-related self-test of the two groups of patients after an operation. Knee function and quality of care are scored using tables. Results. After nursing, the knee joint function score of the instance of watching, noticing, or making a statement group was higher than that of the control group, while the pain after the operation, sleep quality, fear, and stress self-rating scale scores were significantly lower than the control group ( P < 0.05 ). The whole-process management, body position placement, risk evaluation, repairing training, all-weather service, whole-system management, and comprehensive service of the two groups of patients were very much improved. The nursing quality of watching, noticing, or making a statement group was significantly higher than the control group ( P < 0.05 ). Conclusion. Feedforward control combined with 4F management combined with early repairing training can effectively reduce the fear and stress after an operation pain and sleep quality of knee cartilage sports injury and help increase the recovery of knee combined function in a good way.

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“…The beneficial effect of PRP on the meniscus repair failure rate is supported by prior basic science research, because an in vitro and animal study of PRP found the therapy to increase the concentration of various growth factors and upregulate the viability of meniscal cells [ 8 , 14 , 39 ]. Many in vitro studies have demonstrated that the injection of various growth factors could stimulate meniscal tissue repair [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies

Feng

2022

J Orthop Surg Res

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Background There is conflicting clinical evidence whether platelet-rich plasma (PRP) therapies could translate to an increased meniscus healing rate and improved functional outcomes. The objective of this systematic review and meta-analysis was to compare the failure rate and patient-reported functional outcomes in meniscus repair augmented with and without PRP. Methods We comprehensively searched the PubMed, Web of Science, Medline, Embase, and Cochrane Library databases to identify studies that compared the clinical efficacy of meniscus repair performed with PRP versus without PRP. The primary outcome was the meniscus repair failure rate, while the secondary outcomes were knee-specific patient-reported outcomes, including the International Knee Documentation Committee (IKDC) score, Lysholm knee scale, visual analog scale, Tegner activity level score, Western Ontario and McMaster Universities Osteoarthritis Index score, Single Assessment Numeric Evaluation score, and Knee injury and Osteoarthritis Outcome Score. Furthermore, subgroup analyses were performed by stratifying the studies according to the PRP preparation technique to investigate the potential sources of heterogeneity among studies. Results Our meta-analysis included nine studies (two RCTs and seven non-RCTs) with 1164 participants. The failure rate in the PRP group was significantly lower than that in the non-PRP group [odds ratio: 0.64, 95% confidence interval (CI) (0.42, 0.96), P = 0.03]. Furthermore, the PRP group was associated with a statistically significant improvement in the visual analog scale for pain [Mean difference (MD): − 0.76, 95% CI (− 1.32, − 0.21), P = 0.007] and Knee injury and Osteoarthritis Outcome Score-symptom [MD: 8.02, 95% CI (2.99, 13.05), P = 0.002] compared with the non-PRP group. However, neither the IKDC score nor the Lysholm knee scale showed any differences between the two groups. In addition, the results of subgroup analyses favored PRP over platelet-rich fibrin matrix (PRFM) regarding the IKDC score. Conclusions Although meniscus repairs augmented with PRP led to significantly lower failure rates and better postoperative pain control compared with those of the non-PRP group, there is insufficient RCT evidence to support PRP augmentation of meniscus repair improving functional outcomes. Moreover, PRP could be recommended in meniscus repair augmentation compared with PRFM. PRFM was shown to have no benefit in improving functional outcomes.

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Wnt5a/Platelet‐rich plasma synergistically inhibits IL‐1β‐induced inflammatory activity through NF‐κB signaling pathway and prevents cartilage damage and promotes meniscus regeneration

Cited by 22 publications

References 45 publications

Evaluation of the effect of injectionsof both platelet-rich plasma and hyaluronic acid in patients with early knee osteoarthritis via the concentration of interleukin-1β in serum

Evaluation of the effect of injectionsof both platelet-rich plasma and hyaluronic acid in patients with early knee osteoarthritis via the concentration of interleukin-1β in serum

Feedforward Control Combined with 4F Management on Postoperative Nursing Effects and Motor Function of Meniscus Sports Injuries: Based on a Prospective Case Analysis

Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies

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