2011
DOI: 10.1007/s00441-011-1224-4
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Wnt5a plays a crucial role in determining tooth size during murine tooth development

Abstract: We have previously demonstrated that tooth size is determined by dental mesenchymal factors. Exogenous bone morphogenetic protein (BMP)4, Noggin, fibroblast growth factor (FGF)3 and FGF10 have no effect on tooth size, despite the expressions of Bmp2, Bmp4, Fgf3, Fgf10 and Lef1 in the dental mesenchyme. Among the wingless (Wnt) genes that are differentially expressed during tooth development, only Wnt5a is expressed in the dental mesenchyme. The aims of the present study were to clarify the expression pattern o… Show more

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Cited by 27 publications
(30 citation statements)
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“…Despite improved understanding on the involvement of WNT5A in bone development, its roles in the periodontium currently remain unclear. Furthermore, the exogenous addition of WNT5A has been shown to induce cell death in dental and non-dental regions, suggesting that it is involved in cell death (8). In the present study, the expression of WNT5A was weaker in compressed than in non-compressed HCEM.…”
Section: Discussioncontrasting
confidence: 51%
See 1 more Smart Citation
“…Despite improved understanding on the involvement of WNT5A in bone development, its roles in the periodontium currently remain unclear. Furthermore, the exogenous addition of WNT5A has been shown to induce cell death in dental and non-dental regions, suggesting that it is involved in cell death (8). In the present study, the expression of WNT5A was weaker in compressed than in non-compressed HCEM.…”
Section: Discussioncontrasting
confidence: 51%
“…These differences may be caused by the application of compressive force or the characteristics of HCEM. Furthermore, the expression of WNT5A has been shown to increase during tooth development and induces cell death (8). In the present study, the expression of WNT5A was weaker in the compressed group than in the control group, implying that cell death is protected by the inhibition of WNT5A expression.…”
Section: Discussioncontrasting
confidence: 43%
“…The loss of the Wnt5a function experiment, which used Wnt5a-deficient mice to induce the abnormal pattern of cups due to decreased cell proliferation in dental epithelium and mesenchyme, retardation of tooth development, and smaller tooth suggests that Wnt5a regulates growth, patterning, and odontoblast differentiation during odontogenesis [73]. Conversely, the gain of Wnt5a function experiment used exogenous Wnt5a protein to induce cell death in the dental region [74]. Their observations indicate that Wnt5a regulates the balance between cell proliferation and cell death, which involves epithelial and mesenchymal interactions on tooth development.…”
Section: Noncanonical Wnt Signaling Pathway Components In Toothmentioning
confidence: 99%
“…Thus, further studies are necessary to elucidate the role of FGF-10 in urothelium development and maintenance. Normal anorectal development requires communication between the mesenchyme and epithelium through coordinated molecular signaling events that include the FGF-10, wingless-type MMTV integration site family (Wnt), and Sonic hedgehog (Shh) signaling pathways, which are also associated with the lung, tooth and pituitary morphogenesis [Li et al, 2002;Cha et al, 2004;Li et al, 2005;Tai et al, 2009b;Cai et al, 2011]. Disruptions in these cell-cell communications may induce ARM, a diverse set of developmental malformations in mice that range in severity, such as anal atresia, congenital anal fistula and cloacal persistence [Ramalho-Santos et al, 2000;Mo et al, 2001;Fairbanks et al, 2004;Tai et al, 2009b].…”
Section: Discussionmentioning
confidence: 99%