2019
DOI: 10.1186/s12964-019-0419-2
|View full text |Cite
|
Sign up to set email alerts
|

WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling

Abstract: Background Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains the primary cause of death in patients with breast cancer. Basal-like breast cancer (BLBC) is associated with aggressive behavior, stem-like phenotype, high histological grade, poor clinical features, and high rates of recurrences and/or metastasis. However, the mechanism of BLBC phenotype shaping remains obscure. Methods Seventeen normal breast/breast ca… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
40
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 53 publications
(42 citation statements)
references
References 59 publications
2
40
0
Order By: Relevance
“…In recent decades, a growing number of studies have demonstrated that Wnt signaling involves the proliferation [ 9 ], metastasis [ 3 , 10 , 11 ], immune microenvironment regulation [ 3 , 12 ], stemness maintenance [ 13 ], therapeutic resistance [ 14 ], and phenotype shaping [ 15 , 16 ] of breast cancer. Various Wnt signaling inhibitors that act on different targets have been developed, and many of them exhibit potent anticancer potential [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
See 3 more Smart Citations
“…In recent decades, a growing number of studies have demonstrated that Wnt signaling involves the proliferation [ 9 ], metastasis [ 3 , 10 , 11 ], immune microenvironment regulation [ 3 , 12 ], stemness maintenance [ 13 ], therapeutic resistance [ 14 ], and phenotype shaping [ 15 , 16 ] of breast cancer. Various Wnt signaling inhibitors that act on different targets have been developed, and many of them exhibit potent anticancer potential [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…The overexpression of core EMT-TFs has been observed in primary invasive breast cancer and is usually associated with a poor prognosis [ 327 , 330 333 ]. Specifically, Snail [ 224 ], Slug [ 16 , 334 ], Twist1 [ 15 ], ZEB1, and ZEB2 [ 333 ] are commonly overexpressed in BLBCs. While Snail [ 322 , 331 ], Slug [ 321 ], Twist1 [ 335 ], and ZEB1 [ 336 ] are direct targets of Wnt/β-Catenin signaling in breast cancer, ZEB2 is inclined to be an upstream factor of Wnt/β-Catenin signaling [ 337 , 338 ].…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations
“…This study identifies Wnt5b as a key regulator for activating Wnt target genes and EMT markers such as MET, CD44, TCF4, and TWIST1/2, to name a few. Wnt5b knockdown studies conducted via shRNA or by using Porcupine inhibitors resulted in inhibition of tumorigenicity in xenograft model, further signifying the critical role of Wnt5b in BLBC [43]. Some of the evidence implicating Wnt signaling in breast cancer includes elevated levels of β-catenin in the nuclear or cytoplasmic compartments of cancer cells.…”
Section: Breast Cancermentioning
confidence: 99%