Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells

Yang, Hao; Hui, Hui; Wang, Qian; Li, Hui; Zhao, Kai; Zhou, Yuxin; Zhu, Yanxia; Wang, Xiaotang; Qin, You; Guo, Qinglong; Lu, Na

doi:10.18632/oncotarget.2340

Cited by 31 publications

(27 citation statements)

References 50 publications

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“…Cheng et al reported that magnetic nanoparticles of Fe3O4 and Wogonin overcame multidrug resistance K562/A02 cells in vitro [36]. Wogonin induced cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells [37]. Enhancement of apoptosis and reduction of telomerase activity were induced by Wogonin in the HL-60 leukemia cells [38].…”

Section: Discussionmentioning

confidence: 99%

Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway

Zhang

et al. 2014

Biochemical Pharmacology

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Section: Discussionmentioning

confidence: 99%

Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway

Zhang

et al. 2014

Biochemical Pharmacology

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“…Furthermore, it exerts its effect also on differentiation of primary CML cells from patients and on resistant K562 cells probably with a mechanism Bcrabl independent [77].…”

Section: Differentiation Inducers In Aml and CMLmentioning

confidence: 99%

“…Many natural compounds are able to do this in combination or not with the inhibition of Bcr-Abl and finally activate the erythroid transcription factor GATA-1. Wogonin induces erythroid differentiation in K562 cells mediated by activation of GATA-1 and inhibition of Bcr-Abl [77].…”

Section: Differentiation Inducers In Aml and CMLmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

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“…Previous studies (9,10) have demonstrated the antitumor potential of wogonin, particularly its ability to induce apoptosis and its high maximum-tolerated dose. Wogonin has also been observed to be a potential anti-pancreatic cancer drug through its ability to inhibit the Mcl-1 and nuclear factor-κB (NF-κB) pathways (11,12).…”

Section: Introductionmentioning

confidence: 99%

Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells

Sun

Gao

et al. 2016

Oncology Letters

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Wogonin is considered to be an inhibitor of myeloid cell leukemia 1 and B-cell lymphoma 2, and a potential antitumor drug due to its ability to induce apoptosis in certain cancer cells; however, few previous studies have reported on wogonin-induced autophagy. The aim of the present study was to investigate the influence of wogonin on autophagy in human pancreatic cancer cells (HPCCs), elucidate its mechanism, and identify strategies to increase its effectiveness as an anti-cancer treatment. HPCCs were treated with wogonin and autophagy was detected in the cells. The mechanism of wogonin-related autophagy was investigated, and the antioxidant N-acetyl-L-cysteine (NAC) was used to assess the role of reactive oxygen species (ROS) in wogonin-related autophagy. The results demonstrated that wogonin may induce autophagy by activating the Beclin-1/phosphatidylinositol-3-kinase and ROS pathways in HPCCs, and may enhance ROS generation, followed by the activation of the AKT/ULK1/4E-BP1/CYLD pathway and inhibition of the mammalian target of rapamycin signaling pathway. The incubation of HPCCs with wogonin and the antioxidant NAC, revealed that the effects of wogonin-enhanced ROS generation on autophagy-related molecules were inhibited, contributing to the inhibition of autophagy and increasing the cell death ratio through apoptosis activation in HPCCs. These studies suggest that autophagy activation, via the ROS pathway, by the antitumor drug wogonin in HPCCs may partially reduce the antitumor effects of the drug, and that the antioxidant NAC may enhance the antitumor effectiveness of wogonin via the inhibition of ROS-enhanced autophagy and the subsequent promotion of apoptosis. Therefore, the present research suggests that wogonin combined with NAC may be a novel combination therapy for clinical pancreatic cancer therapy trials.

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Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells

Cited by 31 publications

References 50 publications

Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway

Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway

Natural Compounds: Molecular Weapons against Leukemia’s

Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells

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